Leg ulcer nursing care in the community: a prospective cohort study of the symptom of pain
© VanDenKerkhof et al.; licensee BioMed Central Ltd. 2013
Received: 6 September 2012
Accepted: 31 January 2013
Published: 6 February 2013
Chronic wounds are managed almost entirely by community nurses. Almost all individuals with leg ulcers report acute pain usually related to dressing change. Little is known about pain after healing. The purpose of this study was to explore the course of pain from baseline to time of healing of leg ulcers (venous or mixed etiology). In order to understand this phenomenon and develop implications for nursing practice, objectives included: 1) Measure incidence and prevalence of pain at baseline and healing; 2) Describe characteristics associated with leg ulcer pain at baseline; 3) Identify predictors of leg ulcer pain at healing.
Data were from one randomized controlled trial (2004-2008) of 424 individuals with leg ulcers in the community receiving evidence-informed nursing management. The primary outcome was pain at the time of healing. Predictive factors included demographic, circumstance of living, clinical and ulcer characteristics. Multivariable logistic regression identified the subset of predictors of pain at healing. Odds ratios (OR) and 95% confidence intervals (CI) are reported.
Eighty-two percent of participants reported pain at baseline and 32% at healing. Five percent with no pain at baseline reported pain at healing. Thirty-seven percent reported moderate to severe pain at baseline and 11% at healing. Twenty percent of all those who healed reported pain interfered with work moderately to extremely at time of healing. Being female (OR=1.64, 95% CI 1.00, 2.68, p=0.05), use of short-stretch vs. four-layer bandages (OR=1.73, 95% CI 1.06, 2.82, p=0.03), lower SF-12 PCS (OR=0.97, 95% CI 0.94, 0.99, p=0.02) and MCS (OR=0.98, 95% CI 0.95-1.00, p=0.04) scores, use of non-steroidal anti-inflammatory drugs (OR=2.28, 95% CI 1.06, 4.88, p=0.03), and tender pain (OR=2.17, 95% CI 1.29, 3.66, p=<0.01) were associated with pain at time of healing.
Pain is an issue on admission for chronic wounds and at healing, yet 58% with moderate to severe pain on admission were not taking pain medication(s). Future studies should examine the role of pain at healing and at subsequent ulcer recurrence. Mobility and other factors that may contribute to pain at time of healing should also be assessed. Community nurses are encouraged to consider pain when planning care on admission and also after wound healing, when most patients are discharged from care.
KeywordsPain Health-related quality of life Chronic conditions Leg ulcers Community care nursing Longitudinal study, Canada
Pain is one of the five most common reasons for a patient to see a physician. Recent Canadian studies indicate a prevalence of chronic pain of 18%-35%, 80% of which is moderate or severe [1–4]. In the United States, it is estimated that chronic pain costs approximately $560-$635 billion/year (~$60 billion/year in Canada) in direct medical treatment costs and lost productivity . In Canada, pain treatment facility wait-list times often exceed 6-8 months , with most patients suffering from severe pain and depression . Health-related costs for individual wait-listed patients often exceed $20,000 annually . These numbers reaffirm the urgent need to further advance efforts towards the prevention and treatment of persistent pain .
Pain is defined by the International Association for the Study of Pain as “An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” (http://www.iasp-pain.org last accessed Feb 8, 2013). Chronic pain is generally defined as pain lasting beyond tissue healing with duration of at least 3 months. There is growing evidence that pain persists beyond normal healing time after various surgical procedures, and that certain biopsychosocial factors increase the risk of chronic postsurgical pain [10–14]. Few studies have explored potential risk factors and the prevalence and nature of pain during and after healing of chronic wounds, such as leg ulcers. Reports on the prevalence of pain with leg ulcers range from 28% to 93% [15–19], however most studies examine acute pain related to dressing changes. Examining pain reported in the absence of manipulation due to dressing change or after wound healing may be indicative of a chronic pain condition. Pain was a theme reported by 2 of 10 participants in a qualitative study of persons living with healed venous leg ulcers . In a prospective study examining pain and wound healing (venous, mixed venous/arterial, lymphedema-related, and leg and foot ulcers), 52 participants with healed wounds reported an average pain intensity score of 1.67 (out of 10) after healing .
Managing pain with leg ulcers is primarily the role of community care nurses providing leg ulcer care in the home setting [22–25]. Up to 50% of community care-nursing time is spent caring for individuals with ulcers [23, 26–28], and while there is some evidence of acute pain during dressing changes, there is a paucity of information on the trajectory of pain over the course of wound healing. The purpose of this study was to describe pain at entry to treatment and at time of healing in a large cohort of community dwelling adults treated for leg ulcers (venous or mixed etiology). The specific objectives were to: 1) Measure the incidence and prevalence of pain on admission to community care (baseline) and at time of healing; 2) Describe the characteristics associated with leg ulcer pain at baseline; 3) Identify baseline predictors of leg ulcer pain at time of healing.
Individuals with leg ulcers enrolled in a randomized controlled trial between 2004 and 2008 formed the study sample . The primary outcome of the original study was time to ulcer healing (fully epithelialized, no scab, no drainage), with pain and health-related quality of life (HRQL) as secondary outcomes. Healing measures were collected as close to the first observation of healing as possible, typically the same day or the following visit. Baseline and healing assessment data from the trial formed the dataset for the current study. Ethics approval for the trial was received from Queen's University Research Ethics Board, Kingston, Ontario, Canada (REB# NURS-140-03).
As a pragmatic nursing trial several procedures are noteworthy. All participants received a comprehensive evidence-based assessment by their specially trained attending registered nurses in the community care settings located in multiple regions across Canada, including urban centers as well as remote/rural areas. Inclusion criteria for the study were: adult (≥18 years), English-speaking or with access to translation, able to provide written informed consent, clinical presentation of venous insufficiency with an ankle brachial pressure index (ABPI) ≥0.8, and a leg ulcer with minimum duration of one week that measured at least 0.7 cm in any one dimension. Ulcers smaller than 0.7 cm were excluded. Very small ulcers may be difficult to distinguish from skin erosions due to varicose eczema, and are likely to heal rapidly and may not require treatment with compression. Given the reality in community nursing care with this population, an ulcer could be either a first occurrence or recurrent ulcer. Those with medication-controlled diabetes mellitus were excluded. Full trial protocol details are described elsewhere .
For the current study the primary outcome was the prevalence of pain at time of healing. Prevalence was defined as the percent of participants with pain at time of healing. The secondary outcome was the incidence of pain at time of healing. Incidence was defined as the percent of participants with pain at time of healing of those who were free of pain at treatment initiation. Pain specific to the leg ulcer was assessed using the short form McGill Pain Questionnaire (SF-MPQ) [30–32]. The McGill Pain Questionnaire consists of 15 pain descriptors (11 sensory and 4 affective), a visual analogue scale (VAS), and the Present Pain Intensity (PPI). Each pain descriptor can be valued either as “0=none”, “1=mild”, “2=moderate”, or “3=severe”. For the purposes of the analysis values 1 through 3 were recoded as “1-3=present” versus “0=not present”. From the descriptors, sensory, affective, and total pain index scores were generated and standardized out of 100. The VAS is a 100mm scale anchored with “0=no pain” and “10=worst possible pain”. Due to the highly skewed nature of the VAS score, pain was classified in two ways: i) present (VAS>0/10) or absent (VAS = 0); and ii) none/mild (VAS≤3/10) or moderate/severe (VAS>3/10). The PPI is comprised of six number-word combinations ranging from “0=no pain” to “5=excruciating pain”. The SF-MPQ is designed to assess the multidimensional nature of the pain experience and has been demonstrated to be a reliable, valid, and consistent measurement tool . Importantly, it has been used in studies of individuals with leg ulcers and other chronic wounds and found to be a sound approach for clinically assessing the quality of pain with this population .
Predictive factors captured on admission for nursing care (baseline) included demographic and clinical characteristics, and HRQL. Demographic characteristics included age, sex, and circumstance(s) of living. Clinical characteristics included size and duration of ulcer at baseline, time to healing of current ulcer, and mobility and medications for pain control. Baseline characteristics were collected during the comprehensive baseline assessment using interviews and the Leg Ulcer Assessment Tool (LUAT) . HRQL was measured at baseline using the Medical Outcomes Survey Short Form-12 (SF-12) . The SF-12 produces two scores, the Physical Component Summary (PCS) and the Mental Component Summary (MCS). The PCS and MCS are standardized to a mean of 50, with a score above 50 representing better than average and below 50 indicating poorer than average function . A two to three point difference in summary scores is considered clinically meaningful . Individual missing items for the SF-12® were imputed using assignment of mean score (AMS) [35, 36].
Chi-square tests were used to assess the association between categorical variables and the 2-level VAS pain measures at baseline and at time of healing, while independent t-tests were used for continuous variables. Variables with a non-normal distribution were analyzed with appropriate non-parametric procedures, Mann–Whitney U test for unpaired data and Wilcoxon signed ranks test for paired data. Multivariable logistic regression was then used to identify the subset of significant predictors of pain at healing. The primary outcome for the predictive model was defined as pain present at time of healing (VAS>0/10). All regression procedures used simultaneous entry. Variables were eliminated one at a time in successive regressions if p≥0.10, and retained if p<0.10 so as not to miss clinically important trends. Odds ratios (OR) and 95% confidence intervals (CI) are reported for the final multivariable model. Analyses were conducted using IBM© SPSS© (version 20 for Windows).
The association between baseline characteristics and pain at baseline (moderate to severe) and time of healing (any pain)
VAS ≤ 3
VAS > 3
VAS > 0
Non-venous health history
Leg ulcer pain on admission
Pain at rest/night pain
Medications for leg ulcer pain
1 - 2
Previous leg ulcers
Reference ulcer leg
Edema on affected leg
Full flexion on affected leg
Duration of current ulcer (weeks)
Time to healing
Area (cm2) – Tracing
≤ 2.5 cm
> 2.5 to ≤ 10 cm
> 10 cm
ABPI on affected leg*
McGill Pain Indices†
SF-12 Component Summary Scores*
Non-narcotics for leg ulcer pain
NSAIDS for leg ulcer pain
Opiods for leg ulcer pain
Pain at baseline
Pain characteristics at baseline and time of healing
Healing (Pain group)
McGill Pain Indices†
Pain interference with normal work
Not at all
A little bit
Quite a bit
Living with others, taking medication for leg ulcer pain, a history of leg ulcers, prior compression bandaging, shorter duration of reference leg ulcer, and lower MCS scores were associated with moderate to severe pain at baseline in bivariate analysis (Table 1). Rest and night pain were also more likely to be present in individuals with moderate to severe pain at baseline. Participants who were prescribed non-narcotic analgesia and/or opioids were more likely to report moderate to severe pain at baseline (Table 1).
Pain at healing
The prevalence of leg ulcer pain at time of healing was 32% and 3.5% reported moderate to severe pain. The incidence of new leg ulcer pain at time of healing was 5.3%. The median pain sensory and affective scores for the 111 respondents reporting pain at time of healing was 3/100 (25th, 75th percentile 3.0, 9.1) and 0/100 (25th, 75th percentile 0, 0), respectively (Table 2). Twenty percent of all those who healed reported pain interfered with work moderately to extremely. The most commonly reported pain quality descriptors were tender (69%), aching (23%), throbbing (15%), heavy (14%), tiring-exhausting (13%), shooting (11%), and sharp (10%) (Figure 2).
Baseline predictors of pain (VAS > 0) at healing 3
Odds ratio (C.I)
Odds ratio (C.I)
Mild to severe
2.17 (1.29-3.66) -4.2)
This is the first large, quantitative, prospective study to report the trajectory of leg ulcer pain from admission to time of wound healing, when most individuals are discharged from community nursing care service. The results reveal important implications for community nursing practice and care planning.
Pain is clearly an issue for this population both at the time of admission for care and at time of healing and discharge from service. Almost all participants reported pain (87% VAS>0/10; 37% VAS>3/10) at the initiation of leg ulcer treatment and approximately one third reported pain (32% VAS>0/10; 3.5% VAS>3/10) once an ulcer was healed. Approximately 10% of the sample reported pain descriptors (e.g., burning, stabbing, shooting) that are consistent with pain of predominantly neuropathic origin. Baseline predictors of pain at healing were being female, use of short-stretch bandage to treat leg ulcers, pain quality described as tender, and lower SF-12 PCS and MCS scores. Contrary to our expectations, baseline pain was not an independent predictor of pain at time of healing, however use of non–steroidal anti-inflammatory drugs at baseline more than doubled the risk of pain at time of healing. A possible explanation may be that the taking of NSAIDs leads to reduced pain at baseline. Yet the group taking NSAIDS at baseline likely represents those with the most severe pain, and that group, conceivably could have an increased risk of ongoing pain at time of healing. The finding regarding baseline analgesia consumption being a risk factor for chronic pain is consistent with the literature on chronic postsurgical pain, where preoperative pain and opioid use are predictors of persistent pain after surgery . Additional leg ulcer characteristics nurses might expect to predict pain at healing, such as duration and size of ulcer, were also not independent predictors of pain after healing. Finally, we found no other study reporting differences in pain between the two bandaging technolo-gies, therefore the finding that short-stretch bandaging increased the risk of pain at the time of healing, requires further study.
These findings are consistent with the findings in two earlier and smaller studies reporting on pain after healing [20, 21]. Noteworthy is that the prevalence of pain at time of wound healing was not reported in either study. Woo (2009) reported a mean pain score of 1.67/10 in patients with healed ulcers, which is higher than the mean pain score of 0.37 in our study; This higher pain intensity rating reported by Woo may be explained by the inclusion of individuals with foot and/or leg ulcers . The former is known to be more painful than the latter . This ongoing presence of pain after healing supports the notion that a chronic pain condition may develop; possibly neuropathic in nature, due to potential nerve injury, but also potentially due to poorly managed acute nociceptive pain. Several studies highlight the high prevalence and lack of treatment plans to deal with pain with leg ulcers [16, 37, 38]. We found that 58% of those with moderate to severe pain at baseline were not taking medication for leg ulcer pain.
Strengths and limitations
Strengths of this study include the large sample size, prospective nature, consistent evidence-informed follow-up assessments by trained nurses, and large number and range of characteristics that could be examined. Study limitations include the reduced sample size for the follow up analysis due to missing data on some of the baseline characteristics. In particular, some of the pain characteristics were not captured at baseline, possibly because pain was not the primary outcome in the original RCT. If those without pain were less likely to record pain scores, then our findings overestimate the prevalence of pain at healing by up to 3% (29% vs. 32%). Finally, it is possible that the tissue at the site of the ulcer may have remained tender due to nociceptive processes because the assessment was done at time of healing.
Practice implications and future research
Pain with leg ulcers is traditionally associated with treatment and the healing process, however our findings suggest that pain persists at time of healing, which in turn may limit or alter mobility and increase the risk of leg ulcer recurrence. The primary message for clinicians is the need to consider pain as the ‘fifth vital sign’  all the way along the trajectory of healing, including at the time of healing. As accreditation and other oversight bodies include pain with vital signs assessment, it will be increasingly important from a health services and policy perspective as well as being clinically important . Community care nurses should monitor and assist individuals to verbalize and manage their pain both during and after wound healing with pharmaceutical and non-pharmaceutical interventions. It will be important to consider pain issues at the time of care planning on admission as well as at follow-up. Those individuals with pain at time of healing may benefit from remaining on service or being referred to their primary care provider for ongoing follow up until pain is managed or resolves. This may reduce the likelihood of recurrence due to mobility limitations. Although pain scales (e.g. a VAS or Numeric Rating Scale (NRS) measure) are commonly used in practice, the same is not true for documentation of quality of pain. During leg ulcer care, community care nurses can enhance the monitoring of pain by asking patients to describe their pain using ‘pain descriptors’ such shooting, stabbing and burning. This may signify the presence of chronic pain conditions. This will improve the overall management and care planning when additional referrals may be needed.
With the population living with chronic wounds, future studies are needed to track the trajectory of pain from ulcer onset to beyond the time of healing. Importantly this will increase our understanding of whether pain at healing predicts the recurrence of leg ulcers, possibly due to limited mobility. Additionally, longitudinal studies are needed to establish other baseline risk factors for pain during and beyond healing. Intervention studies to better manage acute pain are required to investigate the contribution of nociceptive and/or neuropathic pain in the maintenance of pain once the ulcer is healed. In the interim, community care nurses could focus on providing effective pain management strategies during and after healing with individuals at highest risk of ongoing pain; females with low physical functioning reporting tender pain, and treatment with short stretch bandaging. The current findings provide the basis for a more comprehensive template for community care nurses to conduct their routine evidence-informed assessments of those living with chronic wounds.
The CBT study was funded by a grant from the Canadian Institutes of Health Research (CIHR #63175, CIHR funded trials ISRCTN37782978). The authors would like to thank the Canadian Bandaging Trial (CBT) Group for making this enquiry possible: Arleene Arnold, Maureen Buchanan, Donna Flahr, Connie Harris, Theresa Hurd, Karen Lorimer, Estrella Mercurio, Susan Mills-Zorzes, Mary Catherine Rilett, Laura Teague, and Michelle Todoruk-Orchard. We gratefully acknowledge Elaine Friedberg and Val Angus for coordination and logistical support, and Monica Prince for data management support for the CBT trial. The research team is indebted to the many individuals with leg ulcers who gave generously of their time to participate in the CBT.
- VanDenKerkhof EG, Hopman WM, Towheed TE, Anastassiades TP, Goldstein DH, Canadian Multicentre Osteoporosis Study Research Group: The impact of sampling and measurement on the prevalence of self-reported pain in Canada. Pain Res Manag. 2003, 8: 157-163.View ArticleGoogle Scholar
- Tripp DA, VanDenKerkhof EG, McAlister M: Prevalence and determinants of pain and pain-related disability in urban and rural settings in southeastern Ontario. Pain Res Manag. 2006, 11: 225-233.View ArticlePubMedPubMed CentralGoogle Scholar
- Moulin DE, Clark AJ, Speechley M, Morley-Forster PK: Chronic pain in Canada–prevalence, treatment, impact and the role of opioid analgesia. Pain Res Manag. 2002, 7: 179-184.View ArticlePubMedGoogle Scholar
- Reitsma ML, Tranmer JE, Buchanan DM, VanDenKerkhof EG: The prevalence of chronic pain and pain-related interference in the Canadian population from 1994 to 2008. Chronic Dis Inj Can. 2011, 31: 157-164.PubMedGoogle Scholar
- Institute of Medicine of the National Academies:Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research (Report Brief). 2011,Google Scholar
- Peng P, Choiniere M, Dion D, Intrater H, LeFort S, Lynch M, Ong M, Rashiq S, Tkachuk G, Veillette Y: Challenges in accessing multidisciplinary pain treatment facilities in Canada. Can J Anaesth. 2007, 54: 977-984. 10.1007/BF03016631.View ArticlePubMedGoogle Scholar
- Choiniere M, Dion D, Peng P, Banner R, Barton PM, Boulanger A, Clark AJ, Gordon AS, Guerriere DN, Guertin MC: The Canadian STOP-PAIN project - Part 1: Who are the patients on the waitlists of multidisciplinary pain treatment facilities?. Can J Anaesth. 2010, 57: 539-548. 10.1007/s12630-010-9305-5.View ArticlePubMedGoogle Scholar
- Guerriere DN, Choiniere M, Dion D, Peng P, Stafford-Coyte E, Zagorski B, Banner R, Barton PM, Boulanger A, Clark AJ: The Canadian STOP-PAIN project - Part 2: What is the cost of pain for patients on waitlists of multidisciplinary pain treatment facilities?. Can J Anaesth. 2010, 57: 549-558. 10.1007/s12630-010-9306-4.View ArticlePubMedGoogle Scholar
- Gilron I, Johnson AP: Economics of chronic pain: How can science guide health policy?. Can J Anaesth. 2010, 57: 530-538. 10.1007/s12630-010-9307-3.View ArticlePubMedGoogle Scholar
- Macrae WA, Davies HT: Chronic postsurgical pain.Epidemiology of Pain. Edited by: Crombie IK, Croft PR, Linton SJ, SeResche L, Von Korff M. 1999, Seattle: IASP Press, 125-142.Google Scholar
- Kehlet H, Jensen TS, Woolf CJ: Persistent postsurgical pain: risk factors and prevention. Lancet. 2006, 367: 1618-1625. 10.1016/S0140-6736(06)68700-X.View ArticlePubMedGoogle Scholar
- Macrae WA: Chronic post-surgical pain: 10 years on. Br J Anaesth. 2008, 101: 77-86. 10.1093/bja/aen099.View ArticlePubMedGoogle Scholar
- VanDenKerkhof EG, Hopman WM, Goldstein DH, Wilson RA, Towheed TE, Lam M, Harrison MB, Reitsma ML, Johnston SL, Medd JD: Impact of perioperative pain intensity, pain qualities, and opioid use on chronic pain after surgery: a prospective cohort study. Reg Anesth Pain Med. 2012, 37: 19-27. 10.1097/AAP.0b013e318237516e.View ArticlePubMedGoogle Scholar
- VanDenKerkhof EG, Hopman WM, Reitsma ML, Goldstein DH, Wilson RA, Belliveau P, Gilron I: Chronic pain, healthcare utilization, and quality of life following gastrointestinal surgery. Can J Anaesth. 2012, 59: 670-680. 10.1007/s12630-012-9712-x.View ArticlePubMedGoogle Scholar
- Nemeth KA, Graham ID, Harrison MB: The measurement of leg ulcer pain: Identification and appraisal of pain assessment tools. Adv Skin Wound Care. 2003, 16: 260-267. 10.1097/00129334-200309000-00017.View ArticlePubMedGoogle Scholar
- Nemeth KA, Harrison MB, Graham ID, Burke S: Pain in pure and mixed aetiology venous leg ulcers: a three-phase point prevalence study. J Wound Care. 2003, 12: 336-340.View ArticlePubMedGoogle Scholar
- Nemeth KA, Harrison MB, Graham ID, Burke S: Understanding venous leg ulcer pain: results of a longitudinal study. Ostomy Wound Manage. 2004, 50: 34-46.PubMedGoogle Scholar
- Hofman D, Ryan TJ, Arnold F, Cherry GW, Lindholm C, Bjellerup M, Glynn C: Pain in venous leg ulcers. J Wound Care. 1997, 6: 222-224.PubMedGoogle Scholar
- Moffatt CJ, Franks PJ, Hollinworth H: An international perspective on wound pain and trauma. Ostomy Wound Manage. 2003, 49: 12-14.PubMedGoogle Scholar
- Flaherty E: The views of patients living with healed venous leg ulcers. Nurs Stand. 2005, 19: 78, 80, 82-78, 80, 83.View ArticleGoogle Scholar
- Woo KY, Sibbald RG: The improvement of wound-associated pain and healing trajectory with a comprehensive foot and leg ulcer care model. J Wound Ostomy Continence Nurs. 2009, 36: 184-191. 10.1097/01.WON.0000347660.87346.ed.View ArticlePubMedGoogle Scholar
- Callam MJ, Ruckley CV, Harper DR, Dale JJ: Chronic ulceration of the leg: extent of the problem and provision of care. Br Med J (Clin Res Ed). 1985, 290: 1855-1856. 10.1136/bmj.290.6485.1855.View ArticleGoogle Scholar
- Lees TA, Lambert D: Prevalence of lower limb ulceration in an urban health district. Br J Surg. 1992, 79: 1032-1034. 10.1002/bjs.1800791015.View ArticlePubMedGoogle Scholar
- Nelzen O, Bergqvist D, Lindhagen A, Hallbook T: Chronic leg ulcers: an underestimated problem in primary health care among elderly patients. J Epidemiol Community Health. 1991, 45: 184-187. 10.1136/jech.45.3.184.View ArticlePubMedPubMed CentralGoogle Scholar
- Simon DA, McCollum CN: Approaches to venous leg ulcer care within the community: compression, pinch skin grafts and simple venous surgery. Ostomy Wound Manage. 1996, 42: 34-38. 40PubMedGoogle Scholar
- Moffatt CJ, Franks PJ, Oldroyd M, Bosanquet N, Brown P, Greenhalgh RM, McCollum CN: Community clinics for leg ulcers and impact on healing. BMJ. 1992, 305: 1389-1392. 10.1136/bmj.305.6866.1389.View ArticlePubMedPubMed CentralGoogle Scholar
- Simon DA, Freak L, Kinsella A, Walsh J, Lane C, Groarke L, McCollum C: Community leg ulcer clinics: a comparative study in two health authorities. BMJ. 1996, 312: 1648-1651. 10.1136/bmj.312.7047.1648.View ArticlePubMedPubMed CentralGoogle Scholar
- Ruckley CV: Socioeconomic impact of chronic venous insufficiency and leg ulcers. Angiology. 1997, 48: 67-69. 10.1177/000331979704800111.View ArticlePubMedGoogle Scholar
- Harrison MB, VanDenKerkhof EG, Hopman WM, Graham ID, Carley ME, Nelson EA, and the Canadian Bandaging Trial Group (CBTG): The Canadian Bandaging Trial: Evidence-informed leg ulcer care and the effectiveness of two compression technologies. BMC Nurs. 2011, 10: 20-10.1186/1472-6955-10-20.View ArticlePubMedPubMed CentralGoogle Scholar
- Melzack R: The McGill Pain Questionnaire: Major properties and scoring methods. Pain. 1975, 1: 277-299. 10.1016/0304-3959(75)90044-5.View ArticlePubMedGoogle Scholar
- Melzack R, Katz J: The McGill pain questionnaire: Appraisal and current status.Handbook of Pain Assessment. 1992, 152-168.Google Scholar
- Melzack R: The short-form McGill Pain Questionnaire. Pain. 1987, 30: 191-197. 10.1016/0304-3959(87)91074-8.View ArticlePubMedGoogle Scholar
- Registered Nurses Association of Ontario (RNAO):Nursing Best Practice Guideline: Assessment and Management of Venous Leg Ulcers. 2004, Toronto, Ontario: Registered Nurses Association of Ontario,Google Scholar
- Ware JE, Kosinski M, Keller SD:SF-36 Physical and mental health summary scales: A user manual and interpretation guide. 1994, Boston, Massachusetts: The Health Institute, New England Medical Center,Google Scholar
- Hopman WM, Harrison MB, Carley M, VanDenKerkhof E: Additional support for simple imputation of missing quality of life data in nursing research. ISRN Nursing. 2011, 2011 (752320): 4-Google Scholar
- Perneger TV, Burnand B: A simple imputation algorithm reduced missing data in SF-12 health surveys. J Clin Epidemiol. 2005, 58: 142-149. 10.1016/j.jclinepi.2004.06.005.View ArticlePubMedGoogle Scholar
- Harrison MB, Graham ID, Friedberg E, Lorimer K, Vandevelde-Coke S: Regional planning study. Assessing the population with leg and foot ulcers. Can Nurse. 2001, 97: 18-23.PubMedGoogle Scholar
- Patel NP, Labropoulos N, Pappas PJ: Current management of venous ulceration. Plast Reconstr Surg. 2006, 117: 254S-260S. 10.1097/01.prs.0000222531.84704.94.View ArticlePubMedGoogle Scholar
- Jackson M:Pain: The Fifth Vital Sign. 2002, Toronto: Random House,Google Scholar
- National Pharmaceutical Council: Pain: Current understanding of assessment, management and treatments. National Pharmaceutical Council and the Joint Commission for the Accreditation of Healthcare Organizations. Edited by: Berry PH, Chapman CR, Covington EC, Dahl JL, Katz JA, Miaskowski C, McLean MJ. 2001, http://www.npcnow.org/App_Themes/Public/pdf/Issues/pub_related_research/pub_quality_care/Pain-Current-Understanding-of-Assessment-Management-and-Treatments.pdf. Last access Feb. 8, 2013Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6955/12/3/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.