Prevention and treatment of intertrigo in large skin folds of adults: a systematic review
© Mistiaen and van Halm-Walters; licensee BioMed Central Ltd. 2010
Received: 3 May 2010
Accepted: 13 July 2010
Published: 13 July 2010
Intertrigo in the large skin folds is a common problem. There is a plethora of treatments, but a lack of evidence about their efficacy. A nursing guideline on this matter had to be updated and broadened in scope to other health care professionals.
A systematic review was performed. Thirteen databases were sensitively searched, supplemented by reference tracking and forward citation searches. All types of empirical research relating to the prevention or treatment of intertrigo were included. Study selection, assessment of bias, data-extraction and analysis were done by two independent review-authors.
Sixty-eight studies fulfilled the inclusion criteria. Only 4 studies were RCTs and even these had a considerable risk of bias. Study populations were generally small.
No studies were found about the prevention of intertrigo. The therapies concerned mostly the topical application of antimycotics, corticosteroids, antibiotics, antiseptics or a combination of these. Besides these pharmaceutical interventions, surgical breast reduction was also studied. Although most study-authors were positive, we could not draw firm conclusions about any of the pharmaceutical interventions. Even patients that received placebo intervention showed improvement. There is weak evidence that reduction mammaplasty may be helpful to treat inframammary intertrigo. All research found had considerable risk of bias, prohibiting firm conclusions.
There is no evidence at all about the prevention of intertrigo and there is no firm evidence about its treatment. Well designed studies are needed.
Intertrigo is an inflammatory dermatosis involving body folds that develops through friction of skin to skin and is influenced by moist conditions. Intertrigo is found primarily in the inframammary, inguinal, abdominal and perianal skin folds. Besides these large skin folds, intertrigo may also affect minor skin folds. Intertrigo has been defined as 'an erythematous eruption in a skin fold, caused by warmth, moisture and chafing; it occurs most often in the skin folds under the breasts and in the groin' [1, 2] or as 'a cutaneous inflammatory process on opposing skin surfaces'  or 'an inflammatory dermatosis involving body folds' .
The moist damaged skin can become secondary infected by bacteria or yeast and fungi. Visual symptoms of intertrigo are redness in mirror format and moist skin. Patients may complain of itching, burning feeling, pain and odor [1, 2, 5].
Prevalence of intertrigo in the large skin folds varies from 6% in hospital patients to 17% in nursing home clients and 20% in home care patients [6–12]. There are, to our knowledge, no figures about the prevalence of intertrigo in the general population, largely due to the fact that intertrigo has no specific ICD-10 or ICPC-score. Also there is overlap in medical taxonomies between intertrigo, dermatomycoses and bacterial skin infections.
A nursing guideline on the prevention and treatment of intertrigo was published in the Netherlands in 2004 . For that guideline a systematic review  was performed containing references up to June 2002 and limited to interventions in the nursing domain. The review revealed that there was a plethora of interventions used but a dearth of well designed studies.
In 2009 it was decided that this guideline had to be updated and needed a broader scope, so it could be used by other health professionals as well. Therefore a new, updated and broadened systematic review was required. The aim of this manuscript is to give an overview of the evidence for preventing and treating intertrigo in the large skin folds of adult patients.
A systematic review of the relevant international literature was performed. Two reviewers worked together during all steps of the review.
PUBMED (United States National Library of Medicine)
Embase (Excerpta Medica Database)
The Cochrane Library
(Cochrane Database of Systematic Reviews/Database of Abstracts of Reviews of Effects/Cochrane Central Register of Controlled Trials/Cochrane Methodology Register/Health Technology Assessment Database/NHS Economic Evaluation Database)
CINAHL (Cumulative Index to Nursing and Allied Health Literature)
SCI (Science Citation Index)
(Science Citation Index Expanded/Social Sciences Citation Index/Arts & Humanities Citation Index)
PICARTA (Dutch central library catalogue)
(NCC & OLC)
INVERT (Catalogue of Dutch nursing literature)
NHS-National Library for Health
LILACS (Latin American and Caribbean Health Sciences Literature)
SCIELO (Scientific Electronic Library Online of Brazilian scientific journals)
IMEMR (Index Medicus for the WHO Eastern Mediterranean Region)
AMED (Allied and Alternative MEDicine)
CAMbase (Complementary and Alternative Medicine)
In addition, references from relevant reviews or guidelines found during the above search actions were added to the initial database and a forward search was performed in SCI with the manuscripts that fulfilled the inclusion criteria. All searches were performed begin April 2009.
To be eligible for inclusion, the manuscripts had to meet the following inclusion criteria (in PICO(T)-format):
P atient: Adult patients with (a risk for) intertrigo, which may or may not be infected. The intertrigo has to be located in a major skin fold (inframammary, inguinal, perianal, abdominal or axillary) for the entire or part of the research population
I ntervention: all interventions aimed at the prevention or the treatment of intertrigo
C ontrol: no restrictions
O utcome: the absence/presence of intertrigo or increase/decrease in intertrigo symptoms, assessed by either the patient or a health professional
T ype research: all primary research performed in humans with a sample size >1
Exclusion criteria were research on children, ailments in minor skin folds (e.g. interdigital), diaper dermatitis, specific diseases other than intertrigo ((bv. eczema, Hailey-Hailey disease, pemphigus, granuloma, psoriasis, acanthosis, Darier disease), in vitro research, research on animals, opinion articles, editorials and letters.
Inclusion criteria were assessed firstly on title and abstract (if available) and later on the full-text. The inclusion process was conducted by the two review-authors, independently of each other. Disagreements were discussed until consensus was reached.
Following data were extracted
- General (authors, journal, publication date, country, language)
- Research method (objective, design, analysis)
- Research population (age, gender, setting, sample size)
- Applied (control) interventions (type, dose, frequency, performer)
- Outcomes (type, instrument, time of measurement, frequency, assessor)
- Results & conclusions
The data were extracted by the first review-author and checked by the second.
Data were extracted only for those articles in which the entire research population consisted of patients with intertrigo in the large skin folds or, where these patients formed only part of the research population, for those articles that gave separate analyses for patients with intertrigo in large skin folds.
To assess the risk of bias, the included studies were first divided into comparative or non-comparative studies. Non-comparative studies were all those that used only a single treatment arm. The comparative studies were then further divided into a group where there was no (clear) randomization applied and a group of studies in which patients were allocated by randomization (RCTs). Without further assessment, all non-comparative studies and all comparative studies without randomization were classified as being at high risk of bias. Only the RCTs were further assessed on risk of bias with the screening score instrument that was introduced by NICE in 2009 . This instrument screens for the risk on four types of bias ('selection bias', 'performance bias', 'attrition bias' and 'detection bias'). For each type three questions have to be answered and a conclusion formulated of either 'low risk of bias', 'unclear/unknown risk of bias' or 'high risk of bias'. Studies that scored 'low risk of bias' on all four components received a total score of 'low risk'; studies with 'high risk of bias' on all 4 components were scored totally as 'high risk' and all other combinations as 'unclear/unknown risk of bias'.
Risk of bias assessment was conducted by the two review-authors, independently of each other and disagreements were discussed until consensus was reached.
For the data-synthesis, studies were first categorized to prevention or treatment of intertrigo.
The treatments were than further categorized to (one or more) kind(s) of intervention: antimycotics, corticosteroids, antibiotics, antiseptics, combinations, placebo, surgical and other. For the comparative studies, a distinction was made between studies in which the intervention was compared to the same product but in another dose or frequency and studies in which an intervention was compared to another different intervention (either another therapeutic product, a placebo product or natural course).
It was planned to perform statistical meta-analysis with Review Manager 5.0 (risk ratios for dichotomous outcomes and weighted mean difference for continuous outcomes and both based on a random effects-model) on condition that there was enough statistical and clinical homogeneity.
Seach Results and General Characteristics
The initial searches in the various databases yielded 1989 hits (Additional file 1). After eliminating duplicates 1,124 references were left for the inclusion process. All but 2 databases revealed unique hits.
Initial assessment of the references on title and abstract resulted in 316 references that were retained for full-text inclusion assessment. Of these, three could not be obtained in full-text. After full-text assessment, 136 references were excluded and 177 included.
Of these 177 references, 75 were manuscripts of empirical research on patients of whom all or some suffered from intertrigo in large skin folds. No studies were found with a population that received prevention for intertrigo. The other 102 references were either literature reviews or guidelines. The references of these were entered into the initial database and assessed on the inclusion criteria for this review. This resulted in 62 new references that were not part of the initial database. Twenty-two of these 62 references fulfilled the inclusion criteria and were added to the set for data-extraction.
Together with the 75 references from the initial search and the 22 from the reference tracking we had a set 97 relevant references. All these were than entered into the Science Citation Index for a forward search to find manuscripts that referred to one of these 97 references. This resulted in 58 new references that were assessed on the inclusion criteria, which meant an additional six could be added to the set for data-extraction (totaling 103 references).
These 103 references referred to 100 different studies. Only in 68 studies were separate analyses for intertrigo in large skin folds presented; in the remainder the intertrigo in large skin folds was studied together with other diseases (e.g. all kind of dermatomycoses) or with other locations (large skin folds and interdigital ailments taken together), meaning that no meaningful data extraction or analyses could be done for this systematic review.
The 68 included studies date from 1954 up to 2008. Half of them date from before 1985 and 10% have been published in the last 5 years. The studies originate from 27 different countries; most are from the USA (16 studies), France (9 studies) or Germany and the UK (both 6 studies)). The studies were published in 51 different journals en in 9 different languages (for these the review-authors sought assistance from colleagues who master those specific languages).
Research Designs and Risk of Bias
The 68 studies concerned 52 non-comparative and 16 comparative studies. Most of the non-comparative studies used a post-only design. Of the 16 comparative studies only four used a randomization procedure to allocate the patients to the research conditions. These four RCTs [20–23] were assessed on the risk of bias with the NICE-instrument . None of the four complied with the criteria to qualify as 'low-risk on bias'. The largest problem in these four studies concerned the absence of valid and reliable instruments and methods by which outcomes were measured, resulting in high risk of detection bias. All four RCTs were judged as 'unclear/unknown risk of bias'. All other studies than the RCTs were judged as 'large risk on bias'.
In six of the 16 comparative studies a placebo intervention was used in one of the comparison groups. No study used natural course for comparison.
The number of patients with intertrigo in the large skin folds was rather small (median = 21; mean = 52.7; sd = 78.9; min-max = 1-406). Due to these small samples, there is a priori a considerable chance that the studies could not detect significant differences between groups.
The scientific quality of the studies was hampered even more by the fact that almost all the studies measured their outcomes with self developed instruments that had unclear psychometric properties.
In addition, outcomes were measured at many different moments after the start of therapy, making comparisons between studies difficult.
Another methodological problem was that most papers did not, or not clearly, present the extent to which the interventions and control conditions were implemented as was intended, i.e. in regard to dose, frequency or actor. For example, 'ointment 1 to 4 times a day' or 'for a period of 1 to 4 weeks' are not clear descriptions of an intervention. Likewise, potential confounding co-interventions, e.g. hygienic care of skin folds, were generally not described.
The applied statistics in the papers were not always scientifically sound and accurate. For example, frequencies were sometimes presented for different groups but not statistically tested for significant differences; or sometimes patients that did not respond to their allocated treatment were switched to an alternative group or dropped from further analysis, and in the multicentre studies no multi-level analyses were applied.
Only a minority of the studies declared that there was an approval from an ethics review committee or that patients were asked for informed consent. The financing source was mentioned in only 7 of the 68 studies; in all cases this involved a pharmaceutical company.
All things considered, this means that almost all of the 68 included studies lacked scientific rigor and all the results have to be considered with great caution.
No study addressed the prevention of intertrigo. All studies concerned the treatment of existing intertrigo and mainly the treatment of intertrigo lesions that were already infected (n = 40). In only three studies was it explicitly stated that the research concerned intertrigo that was not yet infected [16, 25, 26]. In the remaining studies the phase/severity of the intertrigo was not clear.
A large variety of therapeutic interventions was applied, with the majority consisting of some kind of topical pharmaceutical treatment (antimycotics, antibiotics, antiseptics, corticosteroids or a combination of these); and in some studies a surgical intervention was employed (Additional file 2).
All therapeutic interventions concerned topical application except for three studies [23, 27, 28] in which antimycotics were given orally. Within the main categories many different products were used and also in various doses, varying frequencies and for varying lengths of time.
The outcome measures applied in the studies can be roughly categorized into (degree of) healing, (decrease in) symptoms (number and/or severity), and tolerance and adverse effects of products
These outcome measures were operationalized in many ways, measured by various (mostly self-developed) instruments and assessed for instance in some studies by laboratory testing, or by physicians, and in other by patients, and measured at different moments. The (degree of) healing was the most frequently used primary outcome.
The large variety of interventions, even within a specific category, and the large variety in outcome measures and measurements caused to large heterogeneity to attempt statistically pooling of results. Therefore results are presented below and in the Additional files 3, 4 and 5 only in a merely descriptive fashion.
Antimycotics were used in 38 studies [20–23, 27–60]. In 25 studies the antimycotic was used as a sole intervention; in the other cases the antimycotic was part of a combination. Only the studies with the antimycotic as a sole intervention are discussed here. Ten studies were comparative, either with the same product but in different form or using another way of administration (n = 4), or with another therapy (n = 4), or with a placebo-intervention (n = 5). Randomization was used in three of these 10 comparative studies.
The mean sample size of patients with intertrigo in the large skin folds in the 25 antimycotic studies was 34.7 patients (sd 59.2, min-max 1-245, median 18).
The applied antimycotics were categorized according to the Dutch Pharmacotherapeutic Compass: antimycotic antibiotics (amphotericine-B , nystatine [39, 40], candidicin , pimaricin ); imidazoles (ketoconazole [27, 28, 31], micozanole , bifonazole , clotrimazole [20, 22], econazole [20, 22, 43, 49, 51, 52], thiabendazole , tioconazole [53, 55]); triazoles (fluconazole ); allylamine (naftifin ) and other antimycotic (cyclopyroxolamine [46, 54], fluorocytosin , dibenzthieen , buclosamide ).
Additional file 3 shows the effects per kind of antimycotic and per kind of study design. For the purpose of overview, doses and frequency are not shown; for each study the number of patients with intertrigo in the large skin folds is presented between brackets (the total population studied may have been larger, if it included also people with intertrigo in other locations or people with other ailments).
Taken into account the weak study designs, no strong conclusions can be drawn. It is remarkable however that the study-authors all drew positive conclusions about the products they studied. So one could say that there is tentative evidence that antimycotics do work in case of infected intertrigo and they are better than placebo interventions. There is no basis to state that one specific preparation is better than another, and there is no reason to assert that oral antimycotics work better than topical ones or vice versa.
In 17 studies [21, 25, 29, 30, 32, 34, 35, 42, 44, 47, 48, 61–66] (Additional file 4) a topical corticosteroïd was used, in four of these as a sole intervention [21, 25, 61, 64]. Only one study  applied randomization to allocate patients.
The mean sample size of patients with intertrigo in the large skin folds in this group of studies was 27.7 patients (sd 33.9, min-max 7-78, median 13).
The four studies in which corticosteroids were used as a sole intervention suggest that corticosteroids do have some effect, and the Hedley study  suggests that hydrocortisone is as effective as the combination of hydrocortisone + miconazole. However, since there are no placebo controlled studies, only one comparative study, and the study populations are small, no firm conclusions can be drawn about the usefulness of corticosteroid application to intertrigo lesions.
An antibiotic was applied in eight studies [30, 32, 33, 35, 48, 50, 62, 65]. However, in all cases the antibiotic was part of a combined preparation (e.g. combined with a corticosteroid). So no conclusions can be drawn about the effectiveness of antibiotics on their own.
In five studies [29, 59, 63, 66, 67] a topical antiseptic was used, but in only one  as a separate intervention. Bonnefoy et al.  compared eosine to the application of cicalfate in symmetrical lesions of the large skin folds in 49 patients; the allocation was not randomized. The general effectiveness was judged to be very good in 40/49 lesions treated with cicalfate versus 31/49 treated with eosine.
Therefore, there is insufficient evidence to draw conclusions about the effectiveness of antiseptics.
In 18 studies [21, 29, 30, 32–35, 42, 44, 47, 48, 50, 59, 60, 62, 63, 65, 66] (Additional file 5) a topical combined preparation was used. Four studies were comparative: two [59, 66] compared a combination to another combination, one  to an antimycotic and one other  to a corticosteroïd.
The combinations usually consisted of an antimycotic and/or a corticosteroid and/or an antibiotic and/or an antiseptic.
The mean sample size of patients with intertrigo in the large skin folds in this group was 27.2 patients (sd 32.8, min-max 2-124, median 15).
Although the study-authors claimed that the combinations worked, no firm conclusions about any of the combinations can be made due to weak research designs and the small sample sizes.
Six studies [20, 22, 36–38, 68] compared an intervention to a placebo intervention, two of the studies [20, 22] were RCTs. The mean sample size of patients with intertrigo in the large skin folds in this group was 57.3 patients (sd 92.6, min-max 4-245, median 21.5).
The placebo intervention was the same as that used as the basis component for the therapeutic comparison, except for the of McMahon study in which water and soap were used as placebo intervention. The placebos were compared to econazole [20, 22], clotrimazole [20, 22], amphotericine-B , candidicin , dibenzthieen  or to water and soap with talcum powder or with gauzes or with barrier cream or with hydrocolloïd .
The Cullen study  contained six patients in the placebo group, one of whom showed completed and three others partial healing. In the Miura study  of 245 lesions, the improved or cured rate was 63% in the placebo group versus 87% in the clotrimazole group vs 74% in the econazole group for patients with candida intertrigo and 40%, 81% and 77% respectively for the tinea cruris patients; there was a significant difference in favor of the clotrimazole group versus the placebo patients, but in the clotrimazole groups there was a larger drop-out rate that may have caused bias. The study of Engel  compared symmetrical lesions of 25 patients, divided between placebo or amphotericine and found that the results were equally good in both groups; in five days of treatment all lesions were 'clear' or 'almost clear' and no sign of recurrence was found after 14 days, regardless of whether they were treated with placebo or with the therapeutic intervention. Franks  included four patients with symmetrical lesions in the large skin folds, that were allocated to either a placebo or candidicine; however, no results were given for the placebo group. Gip  studied symmetrical lesions of 18 patients that were treated either with placebo or with dibenzthieen; after 2 weeks 14/18 lesions in the placebo group showed improvement versus 16/18 in the other group. Finally, McMahon  allocated symmetrical lesions of 14 patients across five groups; evidently with these sample sizes no differences between groups could be found.
In all, it is remarkable in this group of placebo treatments that many patients showed improvement or healing. Apparently, indifferent treatment may also have some effect; maybe it is caused by attention given to skin folds and or the indifferent cream.
Treatment with surgery
We found 15 studies [18, 69–82] with surgical treatment. All studies concerned women with macromastia who underwent some kind of reduction mammaplasty. No study compared the surgical intervention to another intervention, but most gave figures about the preoperative and postoperative prevalence of symptoms. It was not always clear if the preoperative prevalences were actually measured preoperatively or in a retrospective way. The mean sample size for these studies was 138 patients (sd 110.4; min-max 33-406; median 90). In all studies there was a clear finding that the percentage of women with inframammary intertrigo decreased substantially after surgery (varying from 80 tot 100%). Despite the fact that these studies did not compare the intervention to another intervention or to a placebo, they do all point in the same direction with considerable effect in rather large populations. So there is at least weak evidence that reduction mammaplasty helps in solving inframammary intertrigo.
Nine studies [16, 26, 60, 67, 68, 83–86] used interventions that could not be categorized in one of the above treatments. In eight of these the intervention was solitary and in one was it a part of a combination preparation. In three [67, 68, 83] of these eight studies some kind of comparison was made.
The mean sample size of these 8 studies was 17.2 patients (sd 15.3; min-max 3-49; median 11.5).
The products that were studied are melaleuca alternifolia (=tea tree oil) , tacrolimus , betulin , mericleri salt , hamamelis virginiana , polynoxylin , cicalfate , water and soap, water and soap and talcum powder or gauze squares or barrier cream or hydrocolloid .
The study-authors of the non comparative studies all claimed an effect of their product. In the comparative studies, cicalfate was slightly more effective than eosine , while the studies of Alexander  and McMahon  were too small in scale to find differences.
In all, the studies from this group of treatment were very weakly designed and have too small samples to allow some conclusion about their effectiveness.
This systematic review included no studies about the prevention of intertrigo in the large skin folds and 68 studies about the treatment of this condition. All included studies had a number of serious methodological weaknesses, preventing the drawing of any firm conclusions about the effectiveness of the studied interventions.
The treatments examined mostly concerned the topical application of a pharmaceutical product directed at the treatment of superinfecting micro-organisms. Besides these interventions, 15 studies were found about reduction mammaplasty in women with macromastia, and all pointed in the direction that inframammary intertrigo is reduced by this kind of surgery. So there is at least weak but uniform evidence that reduction mammaplasty helps. However, it is doubtful if inframammary intertrigo on itself constitutes sufficient reason to perform such an invasive intervention.
Every review has the potential to miss relevant studies. For example, it is entirely conceivable that more studies were performed, but were published in journals that are not indexed by any of the databases we checked (e.g. Chinese articles might have been missed). Also we haven't searched databases with conference proceedings or databases with ongoing trials. However, searching 13 databases covering manuscripts in many languages is more than usual for a systematic review.
Furthermore, there is a risk that this review may be flawed by publication bias. Perhaps more studies were performed but that have not been published. This is often the case with studies that have no or only negative effects. If this were to be the case, these studies would certainly not change the mean result of no firm evidence found in this review. Formal testing of publication bias by means of funnel plot analysis was not performed since this test requires a well-defined and well-measured effect size in all studies, which was not the case here.
During this review, we were frequently confronted with unclear descriptions of what study-authors meant by intertrigo, how they diagnosed it and how they measured healing progress. This underlines the conclusion that intertrigo deserves more serious attention from the dermatology field on all aspects from defining to diagnosing, pathophysiology, prevention, treatment and evaluation.
In all, this systematic review clearly demonstrates that intertrigo is a greatly under-researched area in dermatology. This also means that the new guideline for which the review was undertaken, will again have to base its recommendations on expert opinion and not on research evidence.
There is no evidence at all about the prevention of intertrigo and there is no firm evidence about its treatment. The treatment of intertrigo of the large skin folds has frequently been studied but only in very weakly designed research. Well designed studies are needed. No firm evidence exists as to which recommendations for a clinical guideline can be formulated.
This study was performed with a grant from ZonMw, the Netherlands Organization for Health Research and Development.
- van Duijn HJ: Intertrigo. Minor ailments in primary care - An evidence based approach. Edited by: Eekhof J, Knuistingh Neven A, Verheij T. 2005, Maarssen: Elsevier Gezondheidszorg, 63-65.Google Scholar
- van Duijn HJ, Mulder J: Kleine kwalen in de huisartsgeneeskunde: smetten onder de borsten. Ned Tijdschr Geneeskd JID - 0400770. 1988, 132: 1842-1843.Google Scholar
- Janniger CK, Schwartz RA, Szepietowski JC, Reich A: Intertrigo and common secondary skin infections. Am Fam Physician. 2005, 72: 833-838.PubMedGoogle Scholar
- Arndt K, Bowers K: Manual of dermatologic therapeutics. 2002, Philadelphia: Lippincott Williams & Wilkins, 6Google Scholar
- Itin P: [Intertrigo--a therapeutic problem circle]. Ther Umsch. 1989, 46: 98-101.PubMedGoogle Scholar
- Halfens RJ, Meijers J, Neyens JCL, Offermans MPW: Rapportage resultaten Landelijke Prevalentiemeting Zorgproblemen. 2008, Maastricht: Maastricht UniversityGoogle Scholar
- Halfens R, Wansink S: Landelijke prevalentiemeting decubitus en andere zorgproblemen: resultaten zevende jaarlijkse meting 2004. 2004, Maastricht: Universiteit MaastrichtGoogle Scholar
- Halfens R, Janssen M, Meijers J: Landelijke prevalentiemeting zorgproblemen: rapportage resultaten 2006. 2006, Maastricht: Universiteit MaastrichtGoogle Scholar
- Mistiaen P, Wagner C, Bours G, Halfens R: Prevalentiemeting van smetten in Nederlandse intramurale zorginstellingen. 2003, Utrecht: NIVELGoogle Scholar
- Mistiaen P, Poortvliet M: Smetten. Landelijke prevalentiemeting zorgproblemen: Rapportage resultaten 2005. Edited by: Halfens R, Janssen M, Meijers J, Mistiaen P. 2005, Maastricht: Universiteit Maastricht, 77-86.Google Scholar
- Halfens R, Meijers J, Neyens J, Offermans M: Landelijke prevalentiemeting zorgproblemen: rapportage resultaten 2007. 2007, Maastricht: Universiteit MaastrichtGoogle Scholar
- McMahon R: The prevalence of skin problems beneath the breasts of in-patients. Nurs Times. 1991, 87: 48-51.PubMedGoogle Scholar
- LEVV, NVDVV, NIVEL: Smetten (intertrigo): preventie en behandeling. landelijke richtlijn verpleging en verzorging. 2004, Utrecht: LEVVGoogle Scholar
- Mistiaen P, Poot E, Hickox S, Jochems C, Wagner C: Preventing and treating intertrigo in the large skin folds of adults: a literature overview. Dermatol Nurs. 2004, 16: 43-57.PubMedGoogle Scholar
- National Institute for Health and Clinical Excellence: The guidelines manual. 2009, London: National Institute for Health and Clinical ExcellenceGoogle Scholar
- Chapman M, Brown J: Tacrolimus 0.1% ointment for intertrigo. J Am Acad Dermatol. 2005, 52: 61-10.1016/j.jaad.2004.04.039.View ArticleGoogle Scholar
- Chapman MS, Brown JM, Linowski GJ: 0.1% tacrolimus ointment for the treatment of intertrigo. Arch Dermatol. 2005, 141: 787-10.1001/archderm.141.6.787-a.View ArticlePubMedGoogle Scholar
- Spector JA, Singh SP, Karp NS: Outcomes after breast reduction - Does size really matter?. Annals of Plastic Surgery. 2008, 60: 505-509. 10.1097/SAP.0b013e31816f76b5.View ArticlePubMedGoogle Scholar
- Spector JA, Karp NS: Reduction mammaplasty: A improvement at any size. Plastic and Reconstructive Surgery. 2007, 120: 845-850. 10.1097/01.prs.0000277660.49802.76.View ArticlePubMedGoogle Scholar
- Cullen SI, Rex IH, Thorne EG: A comparison of a new antifungal agent, 1 percent econazole nitrate (Spectazole(registered trademark)) cream versus 1 percent clotrimazole cream in the treatment of intertriginous candidosis. Curr Ther Res Clin Exp. 1984, 35: 606-609.Google Scholar
- Hedley K, Tooley P, Williams H: Problems with clinical trials in general practice--a double-blind comparison of cream containing miconazole and hydrocortisone with hydrocortisone alone in the treatment of intertrigo. Br J Clin Pract. 1990, 44: 131-135.PubMedGoogle Scholar
- Miura Y, Onuki M, Takahashi S, Seiji M, Akihiko SATO, Kagawa S: A Double-Blind Study on Utility of Econazole Cream in Dermatomycosis. Rinsho Hyoka (Clinical Evaluation). 1979, 7: 83-108.Google Scholar
- Nozickova M, Koudelkova V, Kulikova Z, Malina L, Urbanowski S, Silny W: A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis. Int J Dermatol. 1998, 37: 703-705. 10.1046/j.1365-4362.1998.00541.x.View ArticlePubMedGoogle Scholar
- National Institute for Health and Clinical Excellence: The guidelines manual. 2009, London: National Institute for Health and Clinical ExcellenceGoogle Scholar
- Bergson VS, Franklin WH: Temetex in the treatment of steroid-responsive dermatoses. J Int Med Res. 1977, 5: 33-36.View ArticlePubMedGoogle Scholar
- Schindera I: Current intertrigo therapy - Treatment results with Hamamelis virginiana. Forsch Komplementarmed Klass Naturheilkd. 1999, 6: 31-32. 10.1159/000057145.Google Scholar
- Grigoriu A, Grigoriu D: Superficial mycoses: Ketoconazole treatment. Mykosen. 1982, 25: 258-262.View ArticlePubMedGoogle Scholar
- Puiatti P, Cervetti O, Forte M, Zina G: Ketoconazole treatment in superficial mycoses. Drugs Exp Clin Res. 1986, 12: 405-407.PubMedGoogle Scholar
- Almeyda JJ, Feiwel M, Thorne N, Vickers CF: "Timodine" cream in the treatment of flexural dermatoses and napkin rash. Practitioner. 1974, 213: 864-867.PubMedGoogle Scholar
- Alteras I, Cojocaru I: [Antifungal activity of pimaricin]. Mycoses. 1969, 12: 139-149. 10.1111/j.1439-0507.1969.tb03442.x.View ArticleGoogle Scholar
- Amerighi F, Spagnoli U: Experiments in treatment using ketoconazole in new 2% dermatological powder. G Ital Dermatol Venereol. 1984, 119: XIII-XXVI.PubMedGoogle Scholar
- Anonymous: Estudo da associaçäo de fluprednilideno, sulfato de gentamins e 5-cloro-8-hidroxiquinolina no tratamento de lesoes infectadas/Association of flupredniliden, gentamicin sulphate and 5-chloro-8-hydroxiquinolin in the treatment of infectal lesions. Folha Med. 1989, 99: 45-48.Google Scholar
- Aussems J: [Clinical study of a bufexamac-nystatin-neomycin combination in dermatology]. Brux Med. 1972, 52: 797-799.PubMedGoogle Scholar
- Baran R, Beurey J, Civatte J: Multicentric clinical trial of a new combination of a broad spectrum antimycotic in a dermocorticoid. Sem Hop. 1979, 55: 269-272.PubMedGoogle Scholar
- Durand JR: Clinical trial of a mixture of neomycin, bacitracin, natamycin and dexamethasone. MEDITERR MED. 1975, 3: 71-74.Google Scholar
- Engel MF: Amphotericin B lotion in monilial intertrigo: a double-blind paired comparison study. Arch Dermatol. 1965, 92: 687-10.1001/archderm.1965.01600180079014.View ArticlePubMedGoogle Scholar
- Franks AG, Taschdjian CL, Thorpe GA: Effect of candicidin in intertriginous and paronychial moniliasis. J Invest Dermatol. 1954, 23: 75-76.View ArticlePubMedGoogle Scholar
- Gip L: [Clinical testing of Fungiplex ointment on a geriatric material with intertriginous Candida mycosis]. Dermatol Wochenschr. 1966, 152: 482-484.PubMedGoogle Scholar
- Gisslen H, Hersle K, Mobacken H: Topical treatment of cutaneous candidiasis with 5 fluorocytosine compared with nystatin. Dermatologica. 1974, 148: 362-365. 10.1159/000251929.View ArticlePubMedGoogle Scholar
- Grupper C: [Treatment of some dermatoses caused by yeast fungi (moniliasis of the pyodermitis vegetans type, intertrigo, onyxis and perionyxis) with the new fungicide: mycostatin or nystatin.]. Bull Soc Fr Dermatol Syphiligr. 1954, 61: 495-498.PubMedGoogle Scholar
- Guha DK, Behera FC, Patro SC: Topical therapy with Jadit (Buclosamide) in dermatomycoses. INDIAN J DERMATOL. 1974, 19: 61-63.PubMedGoogle Scholar
- Guilhou E: Miconazole plus hydrocortisone in dermatology. MEDITERR MED. 1979, 7: 22-23.Google Scholar
- Hempel M: [Clinical experiences in the local treatment of dermatomycoses with Econazole lotion]. Mykosen. 1975, 18: 213-219.View ArticlePubMedGoogle Scholar
- Masse R, Nedelec J, Dorval JC: Therapeutic trial of an econazole-triamcinolone combination. OUEST MED. 1980, 33: 157-159.Google Scholar
- Otcenasek M, Pec J, Moravcik P: [Naftifin--laboratory and clinical experience with a new antimycotic from the allylamine group]. Cas Lek Cesk. 1993, 132: 406-409.PubMedGoogle Scholar
- Radovic-Kovacevic V, Ratkovic R, Milenkovic A: [Obytin in the treatment of superficial skin mycoses]. Med Pregl. 1990, 43: 329-331.PubMedGoogle Scholar
- Reiffers J: [Clinical report of triclosan, a new topical with antifungicidal and antimicrobial activity (CGP 433--Logamel) (author's transl)]. Schweiz Rundsch Med Prax. 1981, 70: 1050-1053.PubMedGoogle Scholar
- Rosanove R: "Kenacomb" cream in the treatment of intertrigo. Med J Aust. 1967, 2: 676-678.PubMedGoogle Scholar
- Scherwitz C: [Clinical testing of Econazole skin lotion and cream in dermatomycoses]. Z Hautkr. 1977, 52: 117-125.PubMedGoogle Scholar
- Schmidt P: Therapeutic experience with CG 3225 polyvalent ointment (Topsym). CLIN TRIALS J. 1975, 12: 53-59.Google Scholar
- Schwarz KJ, Much T, Konzelmann M: [Evaluation of econazol in 594 cases of skin mycosis (author's transl)]. Dtsch Med Wochenschr. 1975, 100: 1497-1500. 10.1055/s-0028-1106606.View ArticlePubMedGoogle Scholar
- Siboulet A: [Econazole spray-powder in dermo-venereology (authors transl)]. Schweiz Rundsch Med Prax. 1976, 65: 977-981.PubMedGoogle Scholar
- Somorin AO: Clinical evaluation of tioconazole in dermatophyte infections. Curr Ther Res Clin Exp. 1985, 37: 1058-1061.Google Scholar
- Szepes E, Schneider I: Ciclopiroxolamine in the treatment of dermatomycoses. Mykosen. 1986, 29: 382-386.View ArticlePubMedGoogle Scholar
- Taube KM, Duhr M, Koepke M, Haustein UF: Treatment of fungal infections of the skin with tioconazole. Z DERMATOL. 1995, 181: 125-128.Google Scholar
- Thomas J, Saint-Andre P, Cornudet B: [Local use of thiabendazole in the treatment of certain superficial mycoses]. Bull Soc Pathol Exot Filiales. 1971, 64: 316-322.PubMedGoogle Scholar
- Varma R, Cantrell W, Werlinger K, Elewski BE: A new gel formulation of miconazole nitrate 2% for the treatment of chronic intertrigo. Cosmetic dermatology. 2007, 20: 43-44.Google Scholar
- Vogt G: Intertriginous mycosis and its treatment. ARZTL KOSMETOL. 1985, 15: 178-183.Google Scholar
- Wanic A: [Therapeutic trials of various skin diseases using chinoline and chinaldine derivatives]. Z Haut Geschlechtskr. 1967, 42: 27-32.PubMedGoogle Scholar
- Wurster J: Treatment of intertriginous dermatosis and diaper dermatitis with a combination of econazole and zinc oxide. ARS MED. 1993, 83: 792-795.Google Scholar
- Becker SW: An eight investigator analysis of a newly formulated low dosage corticosteroid. Cutis. 1973, 12: 283-285.Google Scholar
- Gatti JC, Cardama JE, Balina LM: [Our observations with the topical use of Fluocinolone acetonide]. Dia Med. 1963, 35: 1509-PubMedGoogle Scholar
- Hofer P: Treatment of skin diseases with an antiinfective and antiinflammatory gel (Exosterol) containing phenylmercuric borate and dexamethasone pivalate. Praxis. 1974, 63: 1550-1553.PubMedGoogle Scholar
- Marton K, Traore N: Clinical observations on the use of ftorocort ointment in tropical areas. THER HUNG. 1977, 25: 29-31.PubMedGoogle Scholar
- Vallette P, Bonerandi , Sayag J: [Stapolidex in dermatology]. Bull Soc Fr Dermatol Syphiligr. 1968, 75: 490-494.PubMedGoogle Scholar
- Venier A, Carnevali P, Alessandrini A, Urbani S: Controlled clinical trial of a topical formulation of fluocortolone (as privalate and caproate esters) plus chlorquinaldol. CLIN EUR. 1982, 21: 932-939.Google Scholar
- Bonnefoy M, Doss N, Nouira R, Boge T: Comparative study of Cicalfate Lotion(registered trademark) versus eosine for large skin folds intertrigo treatment. Nouv Dermatol. 2008, 27: 257-Google Scholar
- McMahon R: An evaluation of topical nursing interventions in the treatment of submammary lesions. Journal of Wound Care. 1994, 3: 365-366.Google Scholar
- Atterhem H, Holmner S, Janson PE: Reduction mammaplasty: symptoms, complications, and late results. A retrospective study on 242 patients. Scand J Plast Reconstr Surg Hand Surg. 1998, 32: 281-286. 10.1080/02844319850158615.View ArticlePubMedGoogle Scholar
- Brown AP, Hill C, Khan K: Outcome of reduction mammaplasty--a patients' perspective. Br J Plast Surg. 2000, 53: 584-587. 10.1054/bjps.2000.3380.View ArticlePubMedGoogle Scholar
- Davis GM, Ringler SL, Short K, Sherrick D, Bengtson BP: Reduction mammaplasty: long-term efficacy, morbidity, and patient satisfaction. Plast Reconstr Surg. 1995, 96: 1106-1110. 10.1097/00006534-199510000-00015.View ArticlePubMedGoogle Scholar
- Glatt BS, Sarwer DB, O'Hara DE, Hamori C, Bucky LP, LaRossa D: A retrospective study of changes in physical symptoms and body image after reduction mammaplasty. Plast Reconstr Surg. 1999, 103: 76-82. 10.1097/00006534-199901000-00013.View ArticlePubMedGoogle Scholar
- Gonzalez F, Walton RL, Shafer B, Matory J, Borah GL: Reduction mammaplasty improves symptoms of macromastia. Plast Reconstr Surg. 1993, 91: 1270-1276. 10.1097/00006534-199306000-00013.View ArticlePubMedGoogle Scholar
- Heddens CJ: Postoperative survey of reduction mammoplasty patients. Plast Surg Nurs. 1993, 13: 148-155.View ArticlePubMedGoogle Scholar
- Kakagia D, Harkiolakis G, Sgouras N: Symptomatic macromastia: A quality of life evaluation after reduction mammaplasty. Breast J. 1998, 4: 152-155. 10.1046/j.1524-4741.1998.430152.x.View ArticleGoogle Scholar
- Makki AS, Ghanem AA: Long-term results and patient satisfaction with reduction mammaplasty. Ann Plast Surg. 1998, 41: 370-377. 10.1097/00000637-199810000-00004.View ArticlePubMedGoogle Scholar
- McMahan JD, Wolfe JA, Cromer BA, Ruberg RL: Lasting success in teenage reduction mammaplasty. Ann Plast Surg. 1995, 35: 227-231. 10.1097/00000637-199509000-00001.View ArticlePubMedGoogle Scholar
- Moskovitz MJ, Muskin E, Baxt SA: Outcome study in liposuction breast reduction. Plast Reconstr Surg. 2004, 114: 55-60. 10.1097/01.PRS.0000127795.84891.A7.View ArticlePubMedGoogle Scholar
- Rioja Torrejón LF, Pedreño Guerao F, Deza Rodríguez P, Benítez Gumá J, Redondo Camacho A, Haro Padilla JM: [Breast hipertrophy. Aesthetic deformity or it must be included in the national health service]. Cirugía Plástica Ibero-Latinoamericana. 2006, 32: 99-106. 10.4321/S0376-78922006000200004.View ArticleGoogle Scholar
- Schnur PL, Schnur DP, Petty PM, Hanson TJ, Weaver AL: Reduction mammaplasty: an outcome study. Plast Reconstr Surg. 1997, 100: 875-883. 10.1097/00006534-199709001-00008.View ArticlePubMedGoogle Scholar
- Shakespeare V, Cole RP: Measuring patient-based outcomes in a plastic surgery service: breast reduction surgical patients. Br J Plast Surg. 1997, 50: 242-248. 10.1016/S0007-1226(97)91154-1.View ArticlePubMedGoogle Scholar
- Wagner DS, Alfonso DR: The influence of obesity and volume of resection on success in reduction mammaplasty: an outcomes study. Plast Reconstr Surg. 2005, 115: 1034-1038. 10.1097/01.PRS.0000154213.06888.F9.View ArticlePubMedGoogle Scholar
- Alexander JO: Polynoxylin (Anaflex) in dermatology. Br J Dermatol. 1962, 74: 364-371.PubMedGoogle Scholar
- Belaiche P: Traitement des infections cutanees par l'huile essentielle de melaleuca alternifolia.cheel. Phytotherapy. 1985, 15-17.Google Scholar
- Huyke C, Reuter J, Maunz H, Muller ML, Schempp M: Betulin-based ointment for the topical treatment of exudative skin conditions. Merkurstab. 2008, 61: 370-376.Google Scholar
- Profirov D, Nikiforov N: On the antimycotic effect of the Mericleri salt. Folia Med (Plovdiv ). 1974, 16: 143-145.Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6955/9/12/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.