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Table 5 Risk of congenital anomalies among the offspring of RNs according to weighted duration of exposure to antineoplastic drugs (method 2), 1986-2000 (N = 22,491)1,2

From: Cancer incidence and adverse pregnancy outcome in registered nurses potentially exposed to antineoplastic drugs

Congenital anomaly category
(ICD9 code)
Weighted duration of
exposure3
Exposure during first trimester of
pregnancy
Exposure during 10 years preceding
pregnancy
   cases OR4 CI (95%) cases OR4 CI (95%)
All congenital anomalies < 15 days 1,328 1.00   1229 1.00  
(740-759) ≥ 15 days 63 0.93 0.72-1.21 162 0.98 0.82-1.16
Nervous system < 15 days 51 1.00   47 1.00  
(740-742) ≥ 15 days < 3    6 0.96 0.41-2.24
Eye < 15 days 89 1.00   81 1.00  
(743) ≥ 15 days 6 1.31 0.57-3.00 14 1.26 0.71-2.22
Ear, face, neck < 15 days 85 1.00   82 1.00  
(744) ≥ 15 days 4 0.96 0.35-2.64 7 0.64 0.30-1.39
Heart < 15 days 137 1.00   127 1.00  
(745-746) ≥ 15 days 10 1.44 0.75-2.74 20 1.15 0.72-1.84
Other circulatory system < 15 days 127 1.00   115 1.00  
(747) ≥ 15 days 8 1.26 0.61-2.58 20 1.28 0.79-2.06
Cleft palate/lip < 15 days 29 1.00   25 1.00  
(749) ≥ 15 days < 3    6 1.84 0.75-4.49
Upper alimentary tract < 15 days 83 1.00   81 1.00  
(750) ≥ 15 days 4 0.93 0.34-2.55 6 0.55 0.24-1.25
Other digestive system < 15 days 35 1.00   32   
(751) ≥ 15 days < 3    5 1.17 0.46-3.01
Genital organs < 15 days 213 1.00   192 1.00  
(752) ≥ 15 days 6 0.55 0.24-1.25 27 1.06 0.70-1.59
Urinary system < 15 days 101 1.00   93 1.00  
(753) ≥ 15 days 5 0.97 0.39-2.38 13 1.05 0.59-1.88
Musculoskeletal system < 15 days 443 1.00   419 1.00  
(754-756) ≥ 15 days 18 0.80 0.49-1.28 42 0.74 0.54-1.02
Integument < 15 days 96 1.00   88 1.00  
(228, 757) ≥ 15 days 5 1.01 0.41-2.49 13 1.08 0.60-1.94
Chromosomal anomalies < 15 days 60 1.00   56 1.00  
(758) ≥ 15 days < 3    4 0.54 0.20-1.49
Multiple anomalies < 15 days 15 1.00   13 1.00  
(759.7-759.8) ≥ 15 days < 3    3 1.76 0.50-6.19
  1. 1 Congenital anomalies with an incidence of less than 3 cases were excluded.
  2. 2 N for ≥ 15 days of antineoplastic drug exposure during first trimester of pregnancy = 1,062; during 10 years preceding pregnancy = 2,650.
  3. 3 A weighted duration of exposure of 15 days is equivalent to full-time work for one year (240 days) at a job considered unlikely to be exposed; a weighted duration of exposure of 60 days is equivalent to full-time work for one year at a job considered possibly exposed.
  4. 4 Adjusted for sex, year of birth, and age of mother.