Cancer incidence and adverse pregnancy outcome in registered nurses potentially exposed to antineoplastic drugs

BMC Nursing

Table 5 Risk of congenital anomalies among the offspring of RNs according to weighted duration of exposure to antineoplastic drugs (method 2), 1986-2000 (N = 22,491)^1,2

Congenital anomaly category (ICD9 code)	Weighted duration of exposure³	Exposure during first trimester of pregnancy			Exposure during 10 years preceding pregnancy
		cases	OR⁴	CI (95%)	cases	OR⁴	CI (95%)
All congenital anomalies	< 15 days	1,328	1.00		1229	1.00
(740-759)	≥ 15 days	63	0.93	0.72-1.21	162	0.98	0.82-1.16
Nervous system	< 15 days	51	1.00		47	1.00
(740-742)	≥ 15 days	< 3			6	0.96	0.41-2.24
Eye	< 15 days	89	1.00		81	1.00
(743)	≥ 15 days	6	1.31	0.57-3.00	14	1.26	0.71-2.22
Ear, face, neck	< 15 days	85	1.00		82	1.00
(744)	≥ 15 days	4	0.96	0.35-2.64	7	0.64	0.30-1.39
Heart	< 15 days	137	1.00		127	1.00
(745-746)	≥ 15 days	10	1.44	0.75-2.74	20	1.15	0.72-1.84
Other circulatory system	< 15 days	127	1.00		115	1.00
(747)	≥ 15 days	8	1.26	0.61-2.58	20	1.28	0.79-2.06
Cleft palate/lip	< 15 days	29	1.00		25	1.00
(749)	≥ 15 days	< 3			6	1.84	0.75-4.49
Upper alimentary tract	< 15 days	83	1.00		81	1.00
(750)	≥ 15 days	4	0.93	0.34-2.55	6	0.55	0.24-1.25
Other digestive system	< 15 days	35	1.00		32
(751)	≥ 15 days	< 3			5	1.17	0.46-3.01
Genital organs	< 15 days	213	1.00		192	1.00
(752)	≥ 15 days	6	0.55	0.24-1.25	27	1.06	0.70-1.59
Urinary system	< 15 days	101	1.00		93	1.00
(753)	≥ 15 days	5	0.97	0.39-2.38	13	1.05	0.59-1.88
Musculoskeletal system	< 15 days	443	1.00		419	1.00
(754-756)	≥ 15 days	18	0.80	0.49-1.28	42	0.74	0.54-1.02
Integument	< 15 days	96	1.00		88	1.00
(228, 757)	≥ 15 days	5	1.01	0.41-2.49	13	1.08	0.60-1.94
Chromosomal anomalies	< 15 days	60	1.00		56	1.00
(758)	≥ 15 days	< 3			4	0.54	0.20-1.49
Multiple anomalies	< 15 days	15	1.00		13	1.00
(759.7-759.8)	≥ 15 days	< 3			3	1.76	0.50-6.19

¹ Congenital anomalies with an incidence of less than 3 cases were excluded.
² N for ≥ 15 days of antineoplastic drug exposure during first trimester of pregnancy = 1,062; during 10 years preceding pregnancy = 2,650.
³ A weighted duration of exposure of 15 days is equivalent to full-time work for one year (240 days) at a job considered unlikely to be exposed; a weighted duration of exposure of 60 days is equivalent to full-time work for one year at a job considered possibly exposed.
⁴ Adjusted for sex, year of birth, and age of mother.

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