Barriers to timely treatment-seeking in patients with acute myocardial infarction in Malaysia: a qualitative study
© The Author(s). 2016
Received: 2 February 2016
Accepted: 20 May 2016
Published: 28 May 2016
Persisting delay in seeking treatment among Acute Myocardial Infarction (AMI) patients was reported in Malaysia despite intensified efforts in educating the public on symptoms of AMI and the importance of seeking prompt treatment. Studies outside Malaysia have shown that patients’ personal thoughts during symptom onset could contribute to the delay. The purpose of this study is to explore the barriers of AMI patients prior to the decision of seeking treatment in Malaysia.
A qualitative descriptive research approach was chosen. Individual in-depth interviews were conducted among 18 patients with AMI. Data were analysed using thematic analysis. Recordings were transcribed and coded, codes were subsequently organized into categories. The stages of coding and identifying categories were repeated before themes were identified.
Three meaningful themes with nine sub-themes that may have influenced the delayed decision to seek treatment were identified. Some themes identified were culturally bound.
The findings of this study give insights on barriers prior to the decision of seeking treatment when patients were experiencing AMI. Findings indicates that interventions targeted at increasing knowledge about AMI symptoms and correct actions using an informative approach at the current practice may not be adequate to reduce patient delay. The findings of this study could provide basis for the development of interventions that are culturally relevant to the Malaysians setting to promote behavioural change in the population and reduce pre-hospital delay.
KeywordsBarrier Thoughts Beliefs Acute Myocardial Infarction Delay Decision time
Coronary Heart Disease caused 2.3 million deaths globally in 2012 . In Malaysia, it remains the leading cause of death from 2000 to 2012, and accounts for 20.1 % of all deaths in 2012 . Acute Myocardial Infarction (AMI) is the most deadly presentation of Coronary Heart Disease. In-hospital and 30-day mortality following AMI is high at 7 and 13 % respectively in 2010 .
In the management of AMI, delay in seeking treatment after symptom onset could have great consequences on prognosis. Early reperfusion with thrombolytic therapy has been shown to reduce mortality by up to 50 % when it is given within two hours from symptoms onset [4–7]. In Malaysia, thrombolytic therapy constitutes the main reperfusion strategy (74 %) in the treatment of AMI due to limitation of resources for angioplasty in the local hospitals . Efforts have been intensified in Malaysia to reduce the delay to treatment including educating public on symptoms and importance of early treatment for AMI . Despite these efforts, the in-hospital mortality rate for AMI was reported to remain consistent between 8 and 10 % from 2006 to 2010 and it was higher compared to other global registries within the same period . Delay to treatment after symptoms onset has been found as the main cause of high mortality for AMI . A constant mean of this delay was reported between 3.7 and 4.4 h from 2007 to 2012 . In addition, a proportion of AMI patients did not receive any form of primary revascularization therapy because of late presentation leading to missed opportunity for the appropriate therapy .
Symptom onset in this study is defined as the episode of symptoms that has become constant. The symptoms can range from typical chest pain, pain or discomfort in other areas of upper body, to atypical presentations like dizziness, dyspnoea, diaphoresis, weakness, syncope, nausea, and vomiting . Patient delay is the delay from symptom onset to first medical contact . Patient delay represents a combination of two delay intervals: decision time (onset of symptom to decision to seek treatment), and transportation time (decision to seek treatment to hospital arrival). Decision time has been described as the longest interval of delay [12–14]. Improvement could be achieved if factors influencing the delay in this interval are examined. Numerous studies have shown that knowledge about AMI symptoms and the awareness to seek early treatment is not the only determinant influencing the decision time. Studies have described the patients’ personal factors like feelings, emotions, behaviour, and reactions towards AMI symptoms contributed to the delay in decision time [13, 15–19]. Ethnic and cultural differences have also been considered to affect the delay time [14, 20–23].
The context of this study is in Sarawak, which is Malaysia’s largest state. The only government hospital that provides cardiac care service in the state is Sarawak Heart Centre, with eight percent of the total number of heart disease patients in Malaysia being treated in the hospital from 2007 to 2010 . Unpublished data showed that almost half of the AMI patients admitted to Sarawak Heart Centre had a longer delay of more than three hours (Statistic Unit: Time to treatment in AMI, patients admitted from 2010 to 2014, unpublished). In our literature search using databases that include Medline, Cochrane, ScienceDirect, and Cumulative Index to Nursing and Allied Health Literature (CINAHL), few studies described causes of in-hospital delay to treatment in Malaysia, including admission procedures , late referral to cardiologist [25, 26], and inappropriate triage . However, there was no research found in relation to factors influencing the decision time. As there might be cultural, belief, and values differences in the ways AMI symptoms are interpreted in a Malaysian setting, the purpose of this study is to explore the barriers prior to the decision of seeking treatment of AMI patients in Malaysia. We hope that findings from this study will provide insights on patient delay in prehospital phase and assist in improving the current implementations that target at reducing patient delay.
A qualitative descriptive research approach  was chosen because very little is known about the barriers of AMI patients in Sarawak prior to seeking treatment. Individual in-depth interviews were conducted by the first author to gain detailed understanding of the thoughts and meaning constructed by patients when experiencing AMI.
Participants were obtained from the Coronary Care Unit, Sarawak Heart Centre. Purposive sampling was used in this study and the inclusion criteria were patients who were diagnosed with AMI, who were stable hemodynamically, and chest pain-free for at least 48 h. Upon obtaining consent, the patients were interviewed two to five days after the admission. Interviews were conducted in the patients’ cubicle. The setting of Coronary Care Unit enabled a private room for the interviews because each cubicle is only occupied by one patient.
Characteristics of the participants
Patient delay (minutes), mean, range
Onset to decision to seek care
Decision to seek care to hospital arrival
Age, mean, range
History of angina pectoris
Interviews conducted in this study were primarily guided by questions guideline. It is a written list of open-ended questions that need to be covered during the interview. It was designed based on research objective, related literatures, clinical working experience, and improved as interview progressed. The exact order and wording of the questions were different from each patient, and interview conducted always followed new issues that arose. The first main question usually was ‘can you tell me about the first signs you experienced when you had your heart attack’. The subsequent questions were designed to understand the aspects that had delayed their decision to seek treatment. These questions were about the patient’s beliefs and thoughts before any actions that may prolong the decision time. Under these questions, there were probing questions to ensure relevant data could be generated, for example ‘can you tell me more specifically about that?’
Data collection was conducted from July 2012 to February 2013 by the first author. Interviews usually started with greetings and personal conversation. When participants showed their readiness, interview and recording began. Interviews ranged from 21 to 44 minutes. There was no time limit imposed but the interviewer tried to complete the interview within one hour as not to interrupt the ward routine and patients’ rest time. The use of questions guideline helped in the decision on how to utilize the time available and helped the interviewer to elicit data needed from the participants. At the same time, interviews were flexible enough to allow new probing questions as the need arise. The interviewer kept in mind to be respectful, non-judgmental, and non-threatening during interview sessions. Interviews were carried out depending on participants’ preferred language, and were conducted in Malay language for 11 participants and Mandarin for seven participants. The interviewer is familiar and fluent with these two commonly spoken languages in Malaysia. Phone calls were made to 11 participants, who had been discharged from the Coronary Care Unit for verification of interviewer’s interpretations.
Data analysis began as soon as first interview was conducted and continued in parallel with data collection. After analysing transcribed data from the sixteenth participant, no new codes and categories were found. The first author continued to interview two more participants until no new codes and categories emerged from the seventeenth and eighteenth participants’ transcripts. It was decided then that data has reached saturation after 18 interviews because further coding is no longer feasible in the last three participants’ transcripts .
This study used thematic analysis to analyse the data . Participants’ experience, views, feelings, and emotions that had been recorded were transcribed by the first author using participants’ spoken language directly, where no translation to English was made to preserve its nuances . Some words in Mandarin and Malay languages could not be easily conveyed in English and their meaning would lose in translation. The transcripts were read several times by the first author to obtain a sense of whole. Transcripts were then read word by word. The words, phrases, sentences or paragraphs that appear to capture or describe AMI patients’ experience were highlighted and coded. Codes were organized into categories, based on their relationships.
The first author listened through the recordings again and transcripts were referred. The stages of coding and indexing categories were repeated. Some codes flourished and some codes decayed. The codes were re-examined and re-categorized. Exemplars for each code and category were identified from the data. Translation into English was done by the first author for these exemplars. The second and third authors checked the Malay translations by referring to the transcripts to make sure that the translations were accurate and capture the meanings of original language. The Mandarin translations were checked by a physician, who is familiar with Mandarin and English. All authors met regularly to discuss the emerging ideas until reaching an agreement about the categories. Relationships between categories were further identified among the authors with focus to find the consistent and recurrent patterns between categories.
In qualitative research the concepts credibility, dependability, transferability and confirmability have been used to describe various aspects of trustworthiness [34, 35]. To achieve credibility, participants were encouraged to be honest and given the opportunities to decline the research participation. Throughout the process of data collection, the first author kept a memo to write down notes and observations. Memo was referred to during analysis and it helped to conceptualize the data in hand. Member checking was carried out during and after the interviews . During the interviews, the first author would summarize what the participants said and allowed them to immediately correct errors of interpretations. Phone calls were made to 11 participants to verify interviewer’s interpretations during the analysis process. All interviews were recorded, fully transcribed and the first author kept the research aim in mind during the process of coding the data to ensure no relevant data is excluded and no irrelevant data is included. The recordings were listened through again, and transcripts were found accurate in the step reinterpreting categories in data analysis. Agreement was sought from two experts in research methods with the way the data were labelled and sorted. To approach dependability, questions guideline was used to serve as a guideline of questions to be asked or issues to be probed during interview. To strengthen transferability, excerpts were shown to point out the original data in transcripts, where categories were formulated. To achieve confirmability, similar findings from other studies were referred to in the discussion of the findings.
Themes and sub-themes in the decision phase of patients with AMI
Uncertain about their symptoms
Hesitation to seek treatment
Uncertainties to ask for another help
Persuading themselves that symptoms were not life threatening
Denying their symptoms
Belief of being capable to control the symptoms
Belief of being capable to bear the pain
Holding on to their responsibilities
Dealing with expectations
Believing in fate
It was not time yet
Hesitation to seek treatment
Uncertain about their symptoms
‘I never had this pain before. I kept asking myself what is this? I didn’t go to the hospital, because I didn’t know what I was experiencing’ (Lily1).
‘The pain started at six in the morning … I never had this pain before, never… I didn’t know why my chest was painful. I was thinking was it serious? I didn’t feel like going to the hospital yet because I could still bear with it. It was until nine at night that the pain was getting stronger’ (Zainudin).
‘I was having weakness only that day. I had no pain. I felt weakness here (pointing at his left hand), and here (pointing at his left shoulder), and here (pointing at his right shoulder). How would I know it was a heart attack? If it was a heart attack, I would feel the pain at my chest right?’ (Muthu).
Uncertainties to ask for another help
‘I went home after seeing Dr X. I had no appetite for dinner, but I took the medicine. I wanted to sleep earlier at nine, but I couldn’t sleep. The pricking pain was there since morning and I bore with it. Maybe the medicine hasn’t started to work yet. At four in the next morning, the pain was more intense and I couldn’t bear with it anymore’ (Chong).
Denying their symptoms
Persuading themselves that symptoms were not life threatening
‘I told myself maybe I was having dizzy spells because I fell down when I tried to get up. So I didn’t seek any help yet. I was just having giddiness’ (Darrel).
Some participants also expressed that they tried to reassure themselves that the symptoms would subside and would be similar to their previous experience of angina, which only lasted for a while.
Belief of being capable to control the symptoms
‘The first thing I thought when I had the pain was, I want my throat to feel warm so I drank warm water believing that the pain would go away’ (Baidul).
‘When I had the pain after dinner about seven in the evening, I tried to stand up… but I sweated. So I sat on a chair. I called my wife and she massaged my back and my chest. I was still having the pain so I tried to walk around. Then I applied ‘Vick’ ointment on my chest. I looked at the clock and it was already midnight, the ‘Vick’ ointment didn’t reduce my pain’ (Amin).
They eventually sought help when they realized that they could not control the pain and the remedies were not working.
Belief of being capable to bear the pain
‘The pain was getting stronger every minute. I bore with it until I almost fainted’ (Zainudin).
‘I could still bear with it that time. I’m not scared of pain. I’m the one who can bear the highest pain threshold.’ (Bong).
Holding on to their responsibilities
‘That fateful day at around three in the afternoon, I felt a bit of chest pain and difficulty in breathing, then I felt I was going to faint, but I stayed calm, then I continued to work until five. I told my boss, it’s almost five, I shall finish my work first’ (Kenneth).
‘I didn’t go to the hospital. I don’t know. I thought about my family, because we make noodles to earn money. There was a lot of work that I needed to do and they needed me’ (Lily).
Dealing with expectations
‘It never came across my mind that it was a heart attack. I am young you know. Even though after my mother told me it was, I still believed in some way that it was not’ (Hoon).
‘I believe I wasn’t experiencing a heart attack that time. I heard about it before, but I didn’t think about it. I didn’t think the symptoms were related to it. I jog every day and I can jog for one and a half hour without rest.//I always eat fish and vegetables’ (Philip).
Believing in fate
‘The pain went to my back and my neck. I thought it might be time, but I leave it to Allah. Allah knows when I would die, not me. When it is time, we wouldn’t wake up. I wasn’t scared. I accepted my fate and whatever Allah would do to me. I’m His umrah, His people. He’s the leader’ (Rahman).
‘If Allah doesn’t want to give any more time for me, no matter how others help me, how much efforts they use, I would also die… I leave it to Allah… I search for my inner peace. I leave it to Allah, let it be the way Allah wanted to… If Allah still wants to see me tomorrow, then I would survive’ (Asnul).
‘I told my wife, I would have to go (die) first. You go on with your life. Our sons have grown up. They can take care of you. My sons were crying when they heard me saying this. I told my sons how I love their mother and I asked them to take care of her like the way I did’ (Baidul).
It was not time yet
‘If I were to die, I have already died a long time ago, but I survived many events. The time has not come yet. It’s true. We don’t need to worry about being dead or alive. If you are destined to die, you won’t miss it. If you are not, you wouldn’t have any problem’ (Chong).
In this study, the aim was to explore the barriers of AMI patients prior to the decision of seeking treatment in Malaysia. It is hoped the results of this study would provide understandings on the persisting patient delay despite the efforts to increase the awareness of AMI. There are numerous studies examining the barriers outside Malaysia, but the issue has never been studied in the Malaysian setting before. Given that the data were collected until saturation was reached, this study highlights the barriers that may be applicable to many people with similar culture who are experiencing an AMI.
One of the main findings was the uncertainties about the AMI symptoms. The participants in this study described how they hesitated and were unsure of how much pain they should have before they seek help. The hesitation because of uncertainties was also described in two studies in the western countries [18, 37] and such lack of clarity of the symptoms was found central to the delay in seeking treatment. Participants in this study had difficulty in recognising the symptoms as a health threat that requires immediate treatment. For those who consulted general practitioners and were reassured that their symptoms would subside, a period of time was needed by them to verify the need for treatment. In a study that investigated the role of uncertainty in diagnostic information, even a minor reduction in certainty would decrease the urgency of response for high severity threats . The findings in this study suggest that in order to reduce patient delay, certainty of having AMI symptoms is essential during symptom onset. Improvement is necessary in the efforts to educate both the patients and the general practitioners. These efforts require careful planning of effective messages about the typical and atypical AMI symptoms that could occur to help them to recognize and interpret the symptoms correctly.
Under the theme denying their symptoms, findings show that participants denied the pain for few reasons. These were frequently expressed together with the self-persuasion that the symptoms were not serious and would subside. Experiencing sudden AMI symptoms was unexpected for the participants in this study and they never thought of any serious illness because they believed they were still young, healthy, and practising healthy lifestyle. The lack of perceived susceptibility to heart disease has also been described in AMI patients in other countries [39–41] and such somatic under awareness was associated with longer delays [42, 43]. When the participants had such belief, the symptoms were not perceived as a threat. This simple message is lacking in the current health education in Malaysia. It should be emphasized to raise the awareness of AMI risk factors and hopefully would increase the perception of risk for AMI in the population.
Many of the participants in this study were the breadwinners of their family and thus had enormous responsibilities. They had to work to survive and they denied sickness when experiencing the symptoms. This findings were similarly described in two studies in Hong Kong and Korea [14, 23], which found the unique self-sacrificing behaviour in Asian population who tried to maintain their social responsibilities when afflicted by AMI symptoms. Participants in this study tried to fulfil their duties and phrases like ‘shall finish my work first’, ‘thought about family’, or ‘worried if not done’ showed similar self-sacrificing behaviour. Interventions to reduce delay should consider this finding and effort should be made to modify the behaviour which may have prolonged the patients’ decision time to seek treatment.
The findings in this study suggest that perceived control during the episode of AMI may be one of the significant barriers to reduce delay in treatment-seeking. Participants expressed their beliefs of being capable to control symptoms, which led to many self-care remedies. This also can be explained in a way that when participants realized the pain was beyond their control, they then decided to seek treatment. Perceived control is a personal belief that individual has controllability on behalf of one’s self and ability to control threats . Higher perceived control reduced anxiety and is associated with a better psychological and physical outcome in patients with cancer , persistent mental illness  and after myocardial infarction . However, it is different in relation to seeking medical care after the onset of AMI symptoms. Few studies found that a strong personal sense of control predicted longer delay time [48–50]. Hence, behavioural change of individual’s perceived control may be beneficial in the efforts to reduce the delay.
The findings also suggest that participants in this study demonstrated pain resistance behaviour. Participants described how they clenched their teeth and endured the pain until it became unbearable. They explained that they viewed themselves as having the ability to bear the highest degree of pain. Studies in Brazil and Egypt have shown that the pain resistance behaviour was a significant predictor of prolonged prehospital delay in AMI patients [19, 51]. This behaviours could be influenced by the complexities of cultures . The demographics of Malaysia are represented by the multi ethnic groups consisting of Malays and Bumiputera (67.4 %), Chinese (24.6 %), Indians (7.3 %), and others (0.7 %) . Each ethnic in the country has its own distinct culture. There was limited research on cultural attitudes of pain among the multi-ethnic group in Malaysia. Nevertheless, in a study conducted in Singapore, a country that shares similar cultural heritage with Malaysia , it was found that Malay ethnicity had lower pain severity compared with Chinese, and Indian had greater pain severity when compared with both Malay and Chinese ethnicity . The description of cultural influence on the pain resistance behaviour might be limited in this study. However, the thought that they could endure the pain appears to be an important barrier to reduce delay in seeking treatment.
The findings in this study suggest that cultural factor may have influenced the treatment-seeking decisions among the different ethnics of participants in this study. In the findings, one of the reasons for chest pain mentioned by the participants was that there was air trapped in their chest. This description is similar to the findings of one study which was carried out among Malaysian Chinese in a suburban population . Chinese participants in the study believed that joint pain was caused by excessive ‘wind’ accumulated in the joint and abdominal colic was caused by excessive ‘wind’ in the abdomen. This concept of air trapping or excessive wind is embedded in the Malaysian Chinese who practised Taoism . Taoism is mostly practised by Chinese and constitutes 1.3 % of the religion in Malaysia . Taoist believe the yin and yang forces, and disease is a result of an imbalance or blockage in these forces . The influence of the culture could also be seen when participants tried Chinese’s herbs to reduce their pain. Many patients who use traditional Chinese medicine believe that modern medicine is not holistic because it disregards the interaction between the individual and the environment . The findings of this study suggest that such belief may affect the individual response to AMI symptoms and delay the decision to seek appropriate treatment.
To our knowledge, accepting death when experiencing severe pain in AMI has not been described before. In the theme believing in fate, some participants described they were not afraid of death and did not take the initiatives to seek treatment because they believed death is unavoidable and is controlled by Allah in their Islam religion. The findings contrast with prior studies in other countries, in which the thought about intense symptoms would bring death eventually triggered the feeling of fear in their patients and prompted the early decision to seek treatment [58–60]. In a qualitative study conducted in Turkey, AMI patients who described the development of fear of death were effective in their decision-making process and sought immediate treatment . In the context of this study, however, participants’ decision to seek treatment seems to be delayed by their belief in fate. Islam is the most widely professed religion in Malaysia with 61.3 % of its population is Muslim . The concept of fate is fundamental in Islam. Muslim believes that Allah creates human beings, determines their life span and death . Death may become a less stressful event for a Muslim when he truly believes in Islam teaching . Such beliefs, however could be one of the barriers to seek treatment and may be difficult to change.
Fate was also expressed by participants who practised Taoism but its description was different from the participants of Islam religion. They believed they would survive the event despite the severe symptoms because it was not yet their fate to die and hence no urgency to seek treatment. Taoists believe that part of their life is predestined and unchangeable . Death is natural and to fear death is seen as meaningless. What happens after death is not important to Taoists, whose ambition is immortality, the prolongation of physical life . Such beliefs of fate may also be constructed by participants’ personal experience as they mentioned they have survived many events, and this reinforced their reluctance to seek treatment. The findings of this study imply that the awareness of AMI and getting prompt treatment is not the only contributing factor influencing the decision time. The culturally bound beliefs may have influenced their decision of seeking treatment in hospital and could be an important obstacle at the efforts to reduce pre-hospital delay.
Limitations of the present study include the potential recall bias. Patient recalled their thoughts few days before during the interviews. Besides, this study did not recruit AMI patients who did not seek medical care, patients who were not stable to be interviewed during data collection, and patients who died outside the hospital. These patients who could not be recruited might also experience the barriers to seek care.
Persisting pre-hospital delay in AMI patients over the past few years was reported in Malaysia. The findings of this study may provide explanation for the persisting delay as the themes identified give insights on patients’ barriers prior to the decision of seeking treatment when experiencing AMI. The barriers include the uncertainties of their symptoms, denial, self-sacrificing behaviour, perceived control over their symptoms, pain resistance behaviour, and culturally bound beliefs. These responses towards AMI symptoms and culturally bound beliefs may have influenced the patients’ decision to seek treatment. This suggests that current informative approach based on simple messages about knowledge of symptoms, and to get early treatment in the event of these symptoms may not be sufficient to reduce patient delay and need to be reviewed. The findings of this study could provide the basis for the development of interventions that are culturally relevant to the Malaysians setting to promote behavioural change in the population and reduce the pre-hospital delay.
AMI, acute myocardial infarction
All participants’ names were pseudonyms in this study to ensure confidentiality.
We thank all the participants in this study. We also extend our thanks to Dr Ong Tiong Kiam for his permission to recruit patients in Sarawak Heart Centre, Dr Andrew Chang Kean Wei and Matron Tie Suk Foong for their support.
No grants were received from funding agencies.
Availability of data and materials
Data supporting the findings is contained within the manuscript.
All authors contributed to the study design. LSC collected the data, transcribed the interviews, and drafted the first manuscript. All authors contributed to the analysis, interpretation of data. SS did the reviewing and editing of the manuscript. All authors approved the final manuscripts.
The authors declare that they have no competing interests.
Consent for publication
Ethics approval and consent to participate
Ethical approval was obtained from the Research and Ethical Committee of the Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak [Registration number: UNIMAS/TNC(AA)-03.02/06-11; Date: 7th March 2012] and the National Institutes of Health, Ministry of Health Malaysia [Registration number: NMRR-12-170-11516; Date: 4th May 2012]. Before each interview was conducted, informed consent was obtained from every participant. They were given full knowledge of the research process and the right to withdraw from the study at any time without giving any explanation. Permissions to record the interview and the likelihood of receiving phone call by the interviewer for clarification of certain issues after the interview sessions were also obtained from each participant. All participants were assured that their personal data would remain confidential, only pseudonyms names would be used throughout the study and their identities would not be revealed to the reader. Assurance was also given to all participants that only the researcher would have full access to the recording, it would not be released to any third party, and would be erased after completion of this study.
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- WHO. An estimated 12.6 million deaths each year are attributable to unhealthy environments. 2016. Available at: http://www.who.int/mediacentre/news/releases/2016/deaths-attributable-to-unhealthy-environments/en/. Accessed 26 Mar 2016.
- WHO. Malaysia: WHO statistical profile. 2015. Available at: http://www.who.int/gho/countries/mys.pdf?ua=1. Accessed 26 Mar 2016.
- Wan Ahmad WA, Sim KH, editors. Annual Report of the NCVD-ACS Registry, 2009 & 2010. Kuala Lumpur: National Cardiovascular Disease Database; 2013.Google Scholar
- Boersma E, Maas AC, Deckers JW, Simoons ML. Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet Lond Engl. 1996;348(9030):771–5.View ArticleGoogle Scholar
- Bonnefoy E, Steg PG, Boutitie F, Dubien PY, Lapostolle F, Roncalli J, et al. Comparison of primary angioplasty and pre-hospital fibrinolysis in acute myocardial infarction (CAPTIM) trial: a 5-year follow-up. Eur Heart J. 2009;30(13):1598–606.View ArticlePubMedGoogle Scholar
- Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group. Lancet Lond Engl. 1994;343(8893):311–22. Available at: http://www.crd.york.ac.uk/CRDWeb/ShowRecord.asp?ID=11994008029. Accessed 31 Aug 2013.
- Taher T, Fu Y, Wagner GS, Goodman SG, Fresco C, Granger CB, et al. Aborted myocardial infarction in patients with ST-segment elevation: insights from the assessment of the safety and efficacy of a new thrombolytic regimen-3 trial electrocardiographic substudy. J Am Coll Cardiol. 2004;44(1):38–43.View ArticlePubMedGoogle Scholar
- Ministry of Health Malaysia. Clinical practice guidelines: management of acute ST segment elevation myocardial infarction. 3rd ed. Putrajaya: Clinical Practice Guidelines (CPG) Secretariat; 2014.Google Scholar
- Wan Ahmad WA, Sim KH, editors. Annual report of the NCVD-PCI registry year 2010–2012. Kuala Lumpur: National Cardiovascular Disease Database; 2014.Google Scholar
- Kirchberger I, Heier M, Kuch B, von Scheidt W, Meisinger C. Presenting symptoms of myocardial infarction predict short- and long-term mortality: the MONICA/KORA Myocardial Infarction Registry. Am Heart J. 2012;164(6):856–61.View ArticlePubMedGoogle Scholar
- Steg PG, James SK, Atar D, Badano LP, Lundqvist CB, Borger MA, et al. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33(20):2569–619.View ArticlePubMedGoogle Scholar
- Tabriz AA, Sohrabi M-R, Kiapour N, Yazdani S. Factors associated with delay in thrombolytic therapy in patients with ST-elevation myocardial infarction. J Tehran Heart Cent. 2012;7(2):65–71. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466905/. Accessed 21 Mar 2015.Google Scholar
- Johansson I, Strömberg A, Swahn E. Factors related to delay times in patients with suspected acute myocardial infarction. Heart Lung J Crit Care. 2004;33(5):291–300.View ArticleGoogle Scholar
- Kaur R, Lopez V, Thompson DR. Factors influencing Hong Kong Chinese patients’ decision-making in seeking early treatment for acute myocardial infarction. Res Nurs Health. 2006;29(6):636–46.View ArticlePubMedGoogle Scholar
- Taghaddosi M, Dianati M, Fath Gharib Bidgoli J, Bahonaran J. Delay and its related factors in seeking treatment in patients with acute myocardial infarction. ARYA Atheroscler. 2010;6(1):35–41. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347806/. Accessed 31 Aug 2013.PubMedPubMed CentralGoogle Scholar
- Nymark C, Mattiasson A-C, Henriksson P, Kiessling A. Emotions delay care-seeking in patients with an acute myocardial infarction. Eur J Cardiovasc Nurs. 2014;13(1):41–7.View ArticlePubMedGoogle Scholar
- McKinley S, Dracup K, Moser DK, Ball C, Yamasaki K, Kim CJ, et al. International comparison of factors associated with delay in presentation for AMI treatment. Eur J Cardiovasc Nurs. 2004;3(3):225–30.View ArticlePubMedGoogle Scholar
- Rosenfeld AG, Lindauer A, Darney BG. Understanding treatment-seeking delay in women with acute myocardial infarction: descriptions of decision-making patterns. Am J Crit Care. 2005;14(4):285–93. Available at: http://ajcc.aacnjournals.org/content/14/4/285.long. Accessed 2 Dec 2015.PubMedGoogle Scholar
- Mussi FC, Mendes AS, de Queiroz TL, Costa ALS, Pereira Á, Caramelli B, et al. Pre-hospital delay in acute myocardial infarction: judgement of symptoms and resistance to pain. Rev Assoc Médica Bras. 2014;60(1):63–9.View ArticleGoogle Scholar
- Zerwic JJ, Ryan CJ, DeVon HA, Drell MJ. Treatment seeking for acute myocardial infarction symptoms: differences in delay across sex and race. Nurs Res. 2003;52(3):159–67.View ArticlePubMedGoogle Scholar
- Chaturvedi N, Rai H, Ben-Shlomo Y. Lay diagnosis and health-care-seeking behaviour for chest pain in south Asians and Europeans. Lancet Lond Engl. 1997;350(9091):1578–83.View ArticleGoogle Scholar
- McKinley S, Moser DK, Dracup K. Treatment-seeking behavior for acute myocardial infarction symptoms in North America and Australia. Heart Lung J Crit Care. 2000;29(4):237–47.View ArticleGoogle Scholar
- Hwang SY, Jeong MH. Cognitive factors that influence delayed decision to seek treatment among older patients with acute myocardial infarction in Korea. Eur J Cardiovasc Nurs. 2012;11(2):154–9. doi:https://doi.org/10.1016/j.ejcnurse.2010.11.002.View ArticlePubMedGoogle Scholar
- Loke YK, Hwang SL, Tan MH. Delays in thrombolytic therapy in acute myocardial infarction: an audit from the east coast of peninsular Malaysia. Ann Acad Med Singapore. 1997;26(3):285–9. Available at: http://www.ncbi.nlm.nih.gov/pubmed/9285018. Accessed 25 Dec 2015.
- Loch A, Lwin T, Zakaria IM, Abidin IZ, Wan Ahmad WA, Hautmann O. Failure to improve door-to-needle time by switching to emergency physician-initiated thrombolysis for ST elevation myocardial infarction. Postgrad Med J. 2013;89(1052):335–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Azarisman SM, Ngow HA, Melor PA, Fauzi MA, Jamalludin AR, Sapari S, Khairi K, Noorfaizan S, Oteh M. Causes of in-hospital delay for door-to-needle times in patients presenting with acute ST-elevation myocardial infarct in rural Malaysia. Ann Emerg Med. 2008;51(4):530.View ArticleGoogle Scholar
- Lambert VA, Lambert CE. Editorial: qualitative descriptive research: an acceptable design. Pacific Rim Int J Nurs Res. 2012;16(4):255–6. Available at: http://www.tci-thaijo.org/index.php/PRIJNR/article/view/5805/5064. Accessed 14 Oct 2015.
- Alonzo AA. The impact of the family and lay others on care-seeking during life-threatening episodes of suspected coronary artery disease. Soc Sci Med. 1986;22(12):1297–311.View ArticlePubMedGoogle Scholar
- Banks AD, Dracup K. Are there gender differences in the reasons why African Americans delay in seeking medical help for symptoms of an acute myocardial infarction? Ethn Dis. 2007;17(2):221–7. Available at: http://ww.ishib.org/wordpress/?page_id=354. Accessed 14 Oct 2015.PubMedGoogle Scholar
- Ell K, Haywood LJ, Sobel E, deGuzman M, Blumfield D, Ning JP. Acute chest pain in African Americans: factors in the delay in seeking emergency care. Am J Public Health. 1994;84(6):965–70.View ArticlePubMedPubMed CentralGoogle Scholar
- Guest G, Bunce A, Johnson L. How many interviews are enough? An experiment with data saturation and variability. Field Methods. 2006;18(1):59–82.View ArticleGoogle Scholar
- Vaismoradi M, Turunen H, Bondas T. Content analysis and thematic analysis: implications for conducting a qualitative descriptive study. Nursing Health Sci. 2013;15(3):398–405.View ArticleGoogle Scholar
- Halai N. Making use of bilingual interview data: Some experiences from the field. Qual Rep. 2007;12(3):344–55. Available at: https://works.bepress.com/nelofer_halai/15/. Accessed 14 Oct 2015.Google Scholar
- Lincoln YS, Guba EG. Naturalistic inquiry. 1st ed. Beverly Hills: SAGE Publications; 1985. p. 416.Google Scholar
- Graneheim UH, Lundman B. Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nurse Educ Today. 2004;24(2):105–12.View ArticlePubMedGoogle Scholar
- Carlson JA. Avoiding traps in member checking. Qual Rep. 2010;15(5):1102–13. Available at: http://eric.ed.gov/?id=EJ896214. Accessed 14 Oct 2015.
- Clark AM. Treatment decision-making during the early stages of heart attack: a case for the role of body and self in influencing delays. Sociol Health Illn. 2001;23(4):425–46.View ArticleGoogle Scholar
- Cooper AA, Humphreys KR. The uncertainty is killing me: self-triage decision making and information availability. E-J Appl Psychol. 2008;4(1):1–6.View ArticleGoogle Scholar
- Ängerud KH, Brulin C, Eliasson M, Näslund U, Hörnsten Å. The process of care-seeking for myocardial infarction among patients with diabetes. J Cardiovasc Nurs. 2015;30(5):E1–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Cate DT, Gamel CJ, Sol BGM. Awareness, risk perception and behavioural intention in patients with a myocardial infarction. Clin Nurs Stud. 2014;3(2):8–16. doi:https://doi.org/10.5430/cns.v3n2p8.Google Scholar
- Sanderson JDMM. Qualitative descriptive study of Mexican Americans health-seeking experience during myocardial infarction. The University of Texas at Austin. 2014. Available at: https://repositories.lib.utexas.edu/handle/2152/23149. Accessed 25 Dec 2015.
- Vidotto G, Bertolotti G, Zotti A, Marchi S, Tavazzi L. Cognitive and emotional factors affecting avoidable decision-making delay in acute myocardial infarction male adults. Int J Med Sci. 2013;10(9):1174–80.View ArticlePubMedPubMed CentralGoogle Scholar
- Kenyon LW, Ketterer MW, Gheorghiade M, Goldstein S. Psychological factors related to prehospital delay during acute myocardial infarction. Circulation. 1991;84(5):1969–76.View ArticlePubMedGoogle Scholar
- Mardiyono M, Songwathana P, Petpichetchian W. Concept analysis of perceived control. Nurse Media J Nurs. 2011;1(2):225–43. doi:https://doi.org/10.14710/nmjn.v1i2.973.Google Scholar
- Ranchor AV, Wardle J, Steptoe A, Henselmans I, Ormel J, Sanderman R. The adaptive role of perceived control before and after cancer diagnosis: a prospective study. Soc Sci Med. 2010;70(11):1825–31.View ArticlePubMedGoogle Scholar
- Eklund M, Bäckström M. The role of perceived control for the perception of health by patients with persistent mental illness. Scand J Occup Ther. 2006;13(4):249–56.View ArticlePubMedGoogle Scholar
- Moser DK, Riegel B, McKinley S, Doering LV, An K, Sheahan S. Impact of anxiety and perceived control on in-hospital complications after acute myocardial infarction. Psychosom Med. 2007;69(1):10–6.View ArticlePubMedGoogle Scholar
- Riegel B, Elmi A, Moser DK, McKinley S, Meischke H, Doering LV, et al. Who listens to our advice? a secondary analysis of data from a clinical trial testing an intervention designed to decrease delay in seeking treatment for acute coronary syndrome. Patient Educ Couns. 2011;85(2):e33–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Morgan DM. Effect of incongruence of acute myocardial infarction symptoms on the decision to seek treatment in a rural population. J Cardiovasc Nurs. 2005;20(5):365–71.View ArticlePubMedGoogle Scholar
- Lesneski L. Factors influencing treatment delay for patients with acute myocardial infarction. Appl Nurs Res. 2010;23(4):185–90.View ArticlePubMedGoogle Scholar
- Ghazawy ER, Seedhom AE, Mahfouz EM. Predictors of delay in seeking health care among myocardial infarction patients, Minia District, Egypt. Adv Prev Med. 2015;2015:e342361. doi:https://doi.org/10.1155/2015/342361.View ArticleGoogle Scholar
- Rollman GB. Culture and pain. In Kazarian SS, Evans DR, editors. Cultural clinical psychology: theory, research, and practice. New York: Oxford University Press; pp. 267-86.Google Scholar
- Department of Statistics Malaysia: Population distribution and basic demographic characteristic report 2010. Available at: https://www.statistics.gov.my/dosm/index.php?r=column/ctwo&menu_id=L0pheU43NWJwRWVSZklWdzQ4TlhUUT09. Accessed 25 Dec 2015.
- Shiraishi T, editor. Across the causeway: a multi-dimensional study of Malaysia-Singapore relations. Singapore: Utopia Press; 2009.Google Scholar
- Chan A, Malhotra C, Do YK, Malhotra R, Ostbye T. Self reported pain severity among multiethnic older Singaporeans: does adjusting for reporting heterogeneity matter? Eur J Pain. 2011;15(10):1094–9.View ArticlePubMedGoogle Scholar
- Chew KS, Tan TW, Ooi YT. Influence of Chinese culture health beliefs among Malaysian Chinese in a suburban population: a survey. Singapore Med J. 2011;52(4):252–6. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21552785. Accessed 26 Mar 2016.
- Ho NK. Understanding traditional Chinese medicine – a doctor’s viewpoint. Singapore Med J. 2001;42(10):487-492. Available at: https://www.sma.org.sg/publications/smjcurrentissue.aspx?PID=370. Accessed 26 Mar 2016.
- Herlitz J, Thuresson M, Svensson L, Lindqvist J, Lindahl B, Zedigh C, et al. Factors of importance for patients’ decision time in acute coronary syndrome. Int J Cardiol. 2010;141(3):236–42.View ArticlePubMedGoogle Scholar
- Albarqouni L, von Eisenhart Rothe A, Ronel J, Meinertz T, Ladwig K. Frequency and covariates of fear of death during myocardial infarction and its impact on prehospital delay: findings from the multicentre MEDEA Study. Clin Res Cardiol. 2016;105(2):135-144.Google Scholar
- Dubayova T, van Dijk JP, Nagyova I, Rosenberger J, Havlikova E, Gdovinova Z, et al. The impact of the intensity of fear on patient’s delay regarding health care seeking behavior: a systematic review. Int J Public Health. 2010;55(5):459–68.View ArticlePubMedPubMed CentralGoogle Scholar
- Yardimci T, Mert H. Turkish patients’ decision-making process in seeking treatment for myocardial infarction. Jpn J Nurs Sci. 2014;11(2):102–11.View ArticlePubMedGoogle Scholar
- Shokr MB. The metaphorical concept ‘life is a journey’ in the Qur’an: a cognitive-semantic analysis. Linguists List J. 2006;10:94–132.Google Scholar
- Al-Meshhedany AAH, Al-Sammerai NSM. Facing finality: cognitive and cultural studies on death and dying ‘Arabic culture’. Engl Lang Teach. 2010;3(1):12.Google Scholar
- Luo A. Taoist theory of fate. J Renmin Univ China. 2007;03. Available at: http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZRDX200703006.htm. Accessed 25 Dec 2015.
- Hsu C, O’Connor M, Lee S. Understandings of death and dying for people of Chinese origin. Death Stud. 2009;33(2):153–74.View ArticlePubMedGoogle Scholar