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Predictors of home-based cardiac rehabilitation exercise adherence among patients with chronic heart failure: a theory-driven cross-sectional study
BMC Nursing volume 22, Article number: 415 (2023)
Abstract
Background
The factors influencing home-based cardiac rehabilitation exercise adherence among patients with chronic heart failure remain unclear. This study aimed to explore predictors of home-based cardiac rehabilitation exercise adherence in these patients, based on the theory of planned behavior.
Methods
This theory-driven, cross-sectional study used convenience sampling to recruit patients with chronic heart failure undergoing home-based cardiac rehabilitation. Instruments used included the Home-Based Cardiac Rehabilitation Exercise Adherence Scale, the Multidimensional Self-Efficacy for Exercise Scale, the Perceived Social Support Scale, and the Tampa Scale for Kinesiophobia Heart. Multivariate linear hierarchical regression analysis was employed to examine the factors influencing exercise adherence.
Results
A total of 215 patients with chronic heart failure undergoing home-based cardiac rehabilitation participated in the study. The overall score for home cardiac rehabilitation exercise adherence was (48.73 ± 3.92). Multivariate linear hierarchical regression analysis revealed that age (β=-0.087, p = 0.012), education level (β = 0.080, p = 0.020), fear of movement (β=-0.254, p < 0.001), perceived social support (β = 0.451, p < 0.001), and exercise self-efficacy (β = 0.289, p < 0.001) influenced home-based cardiac rehabilitation exercise adherence. In the second model, fear of exercise explained 23.60% of the total variance, while perceived social support and exercise self-efficacy explained 26.60% of the total variance in the third model.
Conclusion
This study found that home-based cardiac rehabilitation exercise adherence in patients with chronic heart failure was suboptimal, and identified its influencing factors. Targeted interventions addressing these factors, such as tailored education, support, and addressing fear of exercise, may help improve exercise adherence.
Introduction
Chronic heart failure is a persistent clinical syndrome caused by structural and/or functional abnormalities of the heart and confirmed by objective evidence [1]. Despite some progress in prevention and control, the clinical prognostic burden of chronic heart failure, such as disability and adverse cardiovascular events, remains significant [2, 3]. Therefore, it is necessary to explore effective interventions to control chronic symptoms and improve clinical prognosis of patients with chronic heart failure.
Cardiac rehabilitation encompasses a variety of approaches designed to help individuals with heart disease achieve optimal physical, mental, and social functioning through their own efforts, thereby enabling them to lead active lives [4, 5]. Exercise-based cardiac rehabilitation has been confirmed to significantly enhance cardiopulmonary function and clinical prognosis in patients with chronic heart failure [6,7,8]. Nevertheless, due to the disease’s chronic nature, long-term outpatient rehabilitation exercises can incur substantial financial and time costs. As a meaningful alternative model [9, 10], unsupervised home-based cardiac rehabilitation has been found to yield comparable benefits to institutional cardiac rehabilitation in terms of improving clinical outcomes, mitigating cardiovascular risks, and cost-effectiveness. Moreover, a series of studies have corroborated that home-based cardiac rehabilitation can bolster exercise endurance and quality of life, foster mental well-being, and curtail readmission rates among patients with chronic heart failure [11,12,13,14].
However, reaping these benefits hinges on long-term adherence to home-based cardiac rehabilitation exercises. Regrettably, it has been reported that long-term adherence among patients with chronic heart failure remains suboptimal [15]. After completing institutional cardiac rehabilitation, only 52% of patients with chronic heart failure participate in home-based exercises [16]. Likewise, 43–63% of these patients are disinclined to engage in regular cardiac rehabilitation exercises due to the persistent nature of their condition and limited exercise endurance [17, 18]. Even with stringent interventions, adherence to long-term (24 months) home cardiac rehabilitation exercises is relatively low (34%) [19]. Similarly, patients demonstrate low adherence to unsupervised home-based cardiac rehabilitation exercise programs in China. According to a study published in the Chinese Journal of Cardiovascular Medicine [20], less than 50% of patients with chronic heart failure comply with the recommended frequency of cardiac rehabilitation exercises, which is three times weekly. Another study that followed up with 283 patients a month after their discharge found that only 64.66% demonstrated good compliance with unsupervised home-based cardiac rehabilitation exercises [21]. Chinese patients often perceive cardiac rehabilitation exercises as an“optional”supplementary therapy rather than an integral part of their treatment, especially in an unsupervised context [22]. Moreover, a lack of professional guidance and support may hinder patients’ confidence and skill development in adhering to the exercise program [23]. Currently, there is no effective solution addressing the lack of sustainability in home-based cardiac rehabilitation exercises, mainly due to unclear influencing factors. Consequently, it is essential to examine the critical determinants affecting patients’ adherence to home-based cardiac rehabilitation exercises, enabling targeted and precise interventions for those with chronic heart failure.
The theory of planned behavior, a behavioral theory, is useful for explaining and predicting home-based cardiac rehabilitation exercise adherence in patients with chronic heart failure. The theory of planned behavior emphasizes that individuals consider their behavioral intention before implementing a specific behavior, which is influenced by their behavioral attitude, subjective norms, and perceived behavioral control, all of which are affected by corresponding individual underlying cognitive basis (Fig. 1) [24]. Behavioral belief refers to an individual’s conscious tendency and confidence in achieving the desired outcomes (exercise self-efficacy in our study), while normative belief is defined as the external expectation for individuals to perform a specific behavior (perceived social support in our study) [24]. Control belief, on the other hand, is regarded as factors that individuals perceive to facilitate or hinder their behavior (exercise fear in our study) [24]. These three beliefs form the foundation and core of the theory of planned behavior, providing a suitable theoretical basis for exploring the predictors of home-based cardiac rehabilitation exercise adherence in patients with chronic heart failure (Fig. 1).
Consequently, this study, as a component of a broader research project, aimed to explore the predictors for home-based cardiac rehabilitation exercise adherence among patients with chronic heart failure. The study focused on the three potential core beliefs (behavioral beliefs, normative beliefs, and control beliefs) derived from the theory of planned behavior, with the intent of identifying targets for intervention and providing a reference for the development of accurate and targeted interventions.
Methods
Participants and samples
This cross-sectional observational study recruited eligible patients with chronic heart failure from a large cardiac rehabilitation center in Liaoning Province, mainland China. The patients were selected using convenient sampling methods during their outpatient clinic visits. The inclusion criteria for participants were: (a) 18 years of age and above; (b) undergoing unsupervised home-based cardiac rehabilitation (they were performing an unsupervised home-based cardiac rehabilitation exercise prescribed by a cardiac rehabilitation physician); (c) voluntary participation in the study. The exclusion criteria were: (a) patients with mental illnesses rendering them unable to communicate normally; (b) patients with other severe organic diseases (e.g. patients with chronic heart failure requiring neurological and pulmonary rehabilitation such as stroke and chronic obstructive pulmonary disease). The sample size was determined using the G-power 3.1.9.7 procedure. To identify predictors of home-based cardiac rehabilitation exercise adherence, the following parameters were set: a medium effect size (f 2) of 0.15, a significance level (α) of 0.05, statistical power (1 − β) of 0.90, and 15 predictors (seven predictive variables from the Socio-Demographic Characteristics Questionnaire, four dimensional variables from the Tampa Scale for Kinesiophobia Heart, and three dimensional variables each from the Perceived Social Support Scale and the Multidimensional Self-Efficacy for Exercise Scale). The minimum required sample size was calculated as 171 cases. To account for a 20% sampling error, the minimum target sample size was set at 206.
Instruments
Socio-demographic characteristics Questionnaire
After a literature review and group discussion, the questionnaire was developed to collect the general socio-demographic characteristics of the participants. The questionnaire covers gender, age, marital status, educational level, duration of disease, monthly income, and place of residence.
Home-based Cardiac Rehabilitation Exercise Adherence Scale
Building on prior constructivist grounded theory research [25], we previously developed a scale to measure home-based cardiac rehabilitation exercise adherence among patients with cardiovascular disease [26]. The scale encompasses 20 items and 4 dimensions, including seeking supports, rehabilitation exercise, exercise monitoring, and information feedback. We utilized a Likert 5-point rating system to collect participants’ responses. The scale ranges from 20 to 100 points, with higher scores indicating better adherence to home-based cardiac rehabilitation exercises. A score of 60 or less is considered low adherence, and a score greater than 60 is considered high adherence.
Tampa Scale for Kinesiophobia Heart
The original scale was developed to assess exercise fear levels in patients with coronary heart disease [27]. Subsequently, this scale has been widely used in patients with chronic heart failure and proved to have good psychometric properties [28, 29]. In this study, the Chinese version of the Tampa Scale for Kinesiophobia Heart was adopted [30]. The scale includes 17 items and 4 dimensions covering perceived danger for heart problem (danger), fear of injury (fear), avoidance of exercise (avoidance), and dysfunctional self (dysfunction). A Likert 4-point rating system was adopted to collect participants’ responses. The scale ranges from 17 to 68 points, with higher scores representing higher levels of exercise fear. In this study, the Cronbach’α coefficient of the scale was 0.790.
Perceived Social Support Scale
In this study, perceived social support in patients with chronic heart failure was measured by the Perceived Social Support Scale [31]. The Chinese version of Perceived Social Support Scale has appropriate reliability and validity [32]. The scale is a 12-item self-report tool covering family support, friend support, and other support. A 7-point Likert rating system was adopted to receive responses from participants. The scale has an overall score ranging from 12 to 84, with higher scores representing higher levels of perceived support. In this study, the Cronbach’α coefficient of the scale was 0.774.
Multidimensional self-efficacy for Exercise Scale
The original scale was developed to measure patients’ confidence in exercise [33]. In this study, the Chinese version of the Multidimensional Self-Efficacy for Exercise Scale was adopted [34]. This scale includes 9 items and 3 dimensions, covering task efficacy, coping efficacy and scheduling efficacy. In addition, each item is rated on a scale of 0 to 10, with 0 being no confidence and 10 being completely confident. The higher the score, the more confident the patient was to keep exercising. In this study, the Cronbach’α coefficient of the scale was 0.763.
Data collection
After being fully informed of the purpose and significance of the study, as well as its voluntary and anonymous nature, 220 patients living with chronic heart failure were invited to participate in the research program during their outpatient follow-ups, with the assistance of clinical nurses. A remarkable 97.73% of them (215 patients) agreed to take part and filled out the questionnaires anonymously in a quiet space after signing an informed consent form. For those with poor eyesight or those who could not fill out the questionnaire on their own, the researchers carefully read out each item one by one. The patients then answered each question verbally, and the researchers recorded their responses. All completed questionnaires were checked thoroughly on site to ensure that the results were accurate and authentic.
Data analysis
In this study, data analysis was performed using SPSS 26.0 software. Continuous variables were presented as mean and standard deviation, while categorical variables were expressed in terms of frequency and proportion. To compare the differences in home-based cardiac rehabilitation exercise adherence across various social demographics, the t-test and analysis of variance were employed. A multiple linear hierarchical stepwise regression analysis was conducted to investigate the factors affecting home-based cardiac rehabilitation exercise adherence in patients with chronic heart failure, based on the theory of planned behavior. A p-value of less than 0.05 was considered statistically significant.
Ethical consideration
All procedures were conducted in accordance to the Declaration of Helsinki of 1964 and its further modifications. Participants were informed of the purpose of the study, the confidentiality of the data, and the voluntary nature of their participation. All participants gave informed forms. The research proposal was approved by the Ethics Review Committee of the First Affiliated Hospital of China Medical University (No. 2023. 66).
Results
Socio-demographic characteristics
The socio-demographic characteristics of the participants are displayed in Table 1. In this study, there were 103 men and 112 women with a mean age of 60.78 years and a standard deviation (SD) of 2.34. A majority of the participants were married (53.5%) and had a monthly income of less than 3,000 RMB (52.1%). Less than half of the participants had completed a secondary education (42.3%) and had been living with the disease for less than 4 years (41.9%).
Home-based cardiac rehabilitation exercise adherence
The overall score for home cardiac rehabilitation exercise adherence in patients with chronic heart failure was (48.73 ± 3.92). The mean scores for the four dimensions covering seeking supports, rehabilitation exercise, exercise monitoring, and information feedback were (12.39 ± 1.78), (12.38 ± 2.00), (11.89 ± 1.70), and (12.07 ± 2.16), respectively.
Socio-demographic differences in based-home cardiac rehabilitation exercise adherence
The between-group differences in home-based cardiac rehabilitation exercise adherence scores are presented in Table 1. The results revealed that the differences in home-based cardiac rehabilitation exercise adherence scores among ages, education levels, and place of residence were statistically significant (p < 0.05).
The correlations between variables
The correlations between various variables in this study are shown in Table 2. The results demonstrated that the total score of exercise self-efficacy (r = 0.377 ~ 0.783, p < 0.001) and the total score of perceived social support (r = 0.272 ~ 0.688, p < 0.001) were positively correlated with the total score of home-based cardiac rehabilitation exercise adherence and its dimensional scores. The total score of fear of movement (r = 0.259 ~ 0.663, p < 0.001) was negatively correlated with the total score of home-based cardiac rehabilitation exercise adherence and its dimensional scores.
Predictors of home-based cardiac rehabilitation exercise adherence
Based on theoretical considerations [24] and literature review, we select three blocks for the stepwise order for entering of predictors. Block 1 contained the general demographic information of the participants. Considering that exercise fear was identified as the strongest predictor of exercise adherence in previous studies, block 2 contained only exercise fear (R2 increased beyond general demographic variables). In addition, block 3 contained perceived social support and exercise self-efficacy (R2 increase after accounting for the influence of exercise fear). Based on the results of univariate analysis and correlation analysis, 6 of 15 variables were selected for hierarchical stepwise regression analysis. In this study, the significant hierarchical stepwise regression analysis model includes 5 of 6 eligible variables, covering age (β=-0.087, p = 0.012), education level (β = 0.080, p = 0.020), fear of movement (β=-0.254, p < 0.001), perceived social support (β = 0.451, p < 0.001), and exercise self-efficacy (β = 0.289, p < 0.001) (Table 3). In addition, the explained variance was 79.3% in the final block 3. Exercise fear explained 23.6% of the total variance, while perceived social support and exercise self-efficacy explained 26.6% of the total variance (Table 3).
Discussion
The practice of home-based cardiac rehabilitation exercise is an essential component in the healthcare management for patients experiencing chronic heart failure [35]. Given that sustained adherence is fundamental to realizing the numerous potential benefits of such practices [36], this study delves deeply into the factors that influence adherence to home-based cardiac rehabilitation among these patients. Strong and growing evidence supports the efficacy of home-based cardiac rehabilitation, citing not only the potential to improve the physiological condition of patients but also the capacity to enhance the quality of life, psychological wellbeing, and health behaviors [11, 37, 38]. The study recognizes the importance of customization, portability, and individual patient autonomy offered by home-based cardiac rehabilitation. It capitalizes on these benefits without sacrificing the clinical supervision that conventional center-based cardiac rehabilitation provides [39]. Identifying targeted factors, this study addresses the interplay of both individual internal resources (like the psychological readiness to adhere) and external resources (like the availability of a conducive home environment or adequate supervision). This comprehensive assessment paves the way for the development of systematic and precise interventions. Through careful adjustments and modifications in an individual’s recovery journey, the long-term adherence to and benefits from home-based cardiac exercise are significantly enhanced.
The findings of this study showed that the level of home-based cardiac rehabilitation exercise adherence among patients with chronic heart failure is relatively low. In terms of various dimensions, the levels of seeking supports, rehabilitating exercise, exercise monitoring, and information feedback are also suboptimal. Seeking supports is the initial adherence behavior of patients with chronic heart failure in home-based cardiac rehabilitation exercise [25]. Disease-related stigma is considered an essential factor hindering patients from seeking supports [40]. Patients with chronic heart failure who experience this stigma may be reluctant to seek supports from others during home-based cardiac rehabilitation exercise, resulting in lower adherence to seeking support. Rehabilitating exercise is the core adherence behavior of patients with chronic heart failure in home-based cardiac rehabilitation exercise [25]. Due to the chronic nature of the disease, patients with chronic heart failure suffer from prolonged adverse symptoms. Consequently, their fear of exercise during home-based cardiac rehabilitation may significantly weaken their courage and confidence in completing these activities [41]. Exercise monitoring is the key adherence behavior of patients with chronic heart failure in home-based cardiac rehabilitation exercise [25]. Limited knowledge may be a significant factor in the low adherence to exercise monitoring among chronic heart failure patients [42]. Those with limited knowledge may not realize the importance of exercise monitoring or recognize the monitoring data. Information feedback is the driving adherence behavior of patients with chronic heart failure in home-based cardiac rehabilitation exercise [25]. Patients with chronic heart failure need to participate in outpatient follow-ups to provide feedback on their home-based cardiac rehabilitation exercises over time. However, a variety of objective barriers, such as limited financial resources and poor transportation, or subjective barriers as measured by the Cardiac Rehabilitation Barriers Scale, may significantly reduce their adherence to outpatient follow-ups for providing relevant feedback [43,44,45]. In summary, for patients with chronic heart failure exhibiting low adherence to home-based cardiac rehabilitation exercise, a series of brief intervention strategies (e.g., contact and education) can be employed, considering the above-mentioned modifiable factors, to enhance their adherence to home-based cardiac rehabilitation exercise.
The results of this study indicate that age and educational level are predictive factors affecting the adherence of chronic heart failure patients to home-based cardiac rehabilitation exercises, consistent with the findings of Pedersen et al. [46]. The older the chronic heart failure patient, the lower the adherence to home-based cardiac rehabilitation exercises. The coexistence of chronic diseases leads to limited exercise endurance in older chronic heart failure patients. Due to physical discomfort, these patients are unwilling to engage in cardiac rehabilitation exercises at home and prefer to rest instead [47]. On the other hand, chronic heart failure patients with a higher level of education exhibit increased adherence to home-based cardiac rehabilitation exercises. According to the knowledge-attitude-practice theory [48], knowledge serves as the foundation for generating attitude, and attitude act as the driving force for individuals to produce practice. Patients with a higher level of education may possess more knowledge about cardiac rehabilitation through internal and external resources [49]. The benefits of cardiac rehabilitation exercises will encourage them to develop positive beliefs, resulting in subsequent participation in these exercises. Based on these findings, during outpatient follow-up periods, particular attention should be given to older chronic heart failure patients and those with lower educational levels, with an emphasis on improving their adherence to home-based cardiac rehabilitation exercises through effective methods of emotional regulation and cognitive education.
In this study, fear of movement is hypothesized and proved to be a control belief within the framework of planned behavior theory. In line with previous research findings [50], fear of movement serves as an independent negative predictor of home-based cardiac rehabilitation exercise adherence among chronic heart failure patients, accounting for 23.6% of the total variation. The higher the level of fear of movement in chronic heart failure patients, the poorer their adherence to home-based cardiac rehabilitation exercises. Chronic heart failure patients experience long-term adverse clinical symptoms such as breathing difficulties and limited exercise endurance [51]. Patients with chronic heart failure may have high fear of exercise due to the aforementioned obstacles. Although these symptoms may be effectively controlled and monitored remotely by physicians, the long-term fear of exercise among patients with chronic heart failure will not be easily eliminated and may prevent them from engaging in beneficial exercise. Among them, exercise self-efficacy may play a strong mediating role [52]. Patients with chronic heart failure with high fear of exercise have a certain negative confidence in completing exercise prescriptions and may not be able to comply with home-based cardiac rehabilitation exercises [53]. Therefore, emotional regulation is indispensable for enhancing the adherence to home-based cardiac rehabilitation exercises among chronic heart failure patients who experience fear of movement.
In addition, the present study’s findings reveal that exercise self-efficacy and perceived social support are independent driving factors affecting the adherence of chronic heart failure patients to home-based cardiac rehabilitation exercises, together accounting for 26.60% of the total variance. Exercise self-efficacy refers to individuals’ belief in their ability and practice to perform physical activities [54]. In this study, exercise self-efficacy is considered as a behavioral belief within the framework of theory of planned behavior. The higher the exercise self-efficacy, the better the adherence of chronic heart failure patients to home-based cardiac rehabilitation exercises. According to the information-motivation-behavioral skills model [55], chronic heart failure patients with higher exercise self-efficacy may possess stronger exercise beliefs and motivation, be more willing to engage in home-based cardiac rehabilitation exercises, or more eager to develop rehabilitation exercise skills or overcome related obstacles [56]. Notably, this represents a positive reinforcement cycle for adherence to home-based cardiac rehabilitation exercises. Based on these findings, exercise self-efficacy may be regarded as a potential target for developing interventions aimed at improving the adherence of chronic heart failure patients to home-based cardiac rehabilitation exercises. Perceived social support refers to the assistance that individuals perceive they receive from external resources in a specific situation [57]. In this study, perceived social support is considered as a normative belief within the framework of the theory of planned behavior. The higher the perceived social support, the better the adherence of chronic heart failure patients to home-based cardiac rehabilitation exercises. Home-based cardiac rehabilitation exercises constitute a highly customized behavioral program, requiring patients to follow prescriptions provided by cardiac rehabilitation professionals [58]. In this process, supports from family members, peers, and professionals is essential for enhancing adherence to home-based cardiac rehabilitation exercises [59]. With the psychological support of family, the experiential support of peers, and the supervisory support from professionals, chronic heart failure patients can gain higher confidence and courage to complete the prescribed cardiac rehabilitation exercise tasks at home [60]. This remains a positive reinforcement cycle for exercise adherence. Therefore, social support may serve as a powerful external resource for improving adherence to home-based cardiac rehabilitation exercises among chronic heart failure patients. Different aspects of support from family, peers, and professionals should be incorporated into the home-based cardiac rehabilitation program to enhance patients’ adherence.
Our study is grounded on the central beliefs of the theory of planned behavior, covering behavioral, normative, and control beliefs. The theory of planned behavior serves as a comprehensive framework for forecasting health-related actions at an individual level. In this context of our research, we proposed that the degree of belief in one’s capability to exercise successfully (exercise self-efficacy), the level of support a person feels they receive from others (perceived social support) and fear of exercising (exercise fear), each correlating with behavioral, normative, and control beliefs respectively, could be the significant predictors of adherence to exercise regimen in patients experiencing chronic heart failure. Confirming our hypothesis, our primary results showed that exercise self-efficacy, perceived social support, and exercise fear - each grounded in the theory of planned behavior - emerge as forceful predictors, and collectively explain 50.20% of fluctuation in commitment to exercise amongst patients experiencing chronic heart failure. Specifically, the theory of planned behavior suggests that those who have faith in their power to carry out the exercise (a high degree of exercise self-efficacy) are more prone to stick to a home-based cardiac rehabilitation program. Additionally, our study found that individuals who felt a greater amount of social support were more often compliant with an exercise regime. On the other hand, fear of exercise could discourage patients from participating in an exercise regime, indicating a lower extent of perceived behavioral control and as a result, causing lesser adherence. Overall, these explanations not only stress the significance of our findings but also spotlight the critical role of the theory of planned behavior in understanding and predicting health-oriented behaviors among patients suffering from chronic heart failure.
Limitation
There are several limitations that need to be discussed in this study. First, a larger, multi-center sample should be considered to supplement the results of this study, although the sample size is sufficient for the current investigation. Furthermore, biases arising from convenience sampling are unavoidable. As a result, a 20% sampling error is taken into account in this study. Lastly, the predictive factors for adherence to home-based cardiac rehabilitation exercise among chronic heart failure patients have been identified, but the causal relationship pathways have not yet been explored. This will be considered in our future research. In addition, limited predictors were included in this study, and a more comprehensive exploration of predictors of adherence to home-based cardiac rehabilitation exercise in patients with chronic heart failure is also the focus of our future research work.
Conclusion
This study investigates the factors affecting home-based cardiac rehabilitation exercise adherence among patients with chronic heart failure. Adherence to home-based cardiac rehabilitation exercises in these patients is found to be at a relatively low level. Special attention should be given to older patients and those with lower educational attainment. Additionally, social support and self-efficacy may serve as potential intervention targets to improve the adherence of chronic heart failure patients to home-based cardiac rehabilitation exercises.
Data Availability
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
The authors are grateful to patients with chronic heart failure who participated in this study, and also to the health providers for their strong support in sampling.
Funding
The study was supported by 2022 Clinical Nursing Research Project of Nursing Branch of China Research Hospital Society (Project number: Y2022FH-HLFH06-04). This funding source had no role in the design of this study and had no role during its execution, statistical analysis, interpretation of the data, or decision to submit results.
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ZY was responsible for the research design, data collection, analysis and interpretation of results, and manuscript preparation. HHJ contributed to the analysis and interpretation of results. APW played a central role in designing, advised on the overall research process, and helped prepare the manuscript. All authors have read and approved the final manuscript.
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All procedures were conducted in accordance to the Declaration of Helsinki of 1964 and its further modifications. Participants were informed of the purpose of the study, the confidentiality of the data, and the voluntary nature of their participation. All participants gave informed consent forms. The research proposal was approved by the Ethics Review Committee of the First Affiliated Hospital of China Medical University (No. 2023. 66).
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Yang, Z., Jia, H. & Wang, A. Predictors of home-based cardiac rehabilitation exercise adherence among patients with chronic heart failure: a theory-driven cross-sectional study. BMC Nurs 22, 415 (2023). https://doi.org/10.1186/s12912-023-01566-5
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DOI: https://doi.org/10.1186/s12912-023-01566-5